Calcium phosphate cement-magnesium alloy composite scaffold for diaphyseal fracture fixation: a hypothesis

Abstract

For the treatment of long bone diaphyseal fractures, traditional orthopedic implants have limitations such as stress shielding, non-degradability, and soft tissue damage. In this study, we proposed a hypothesis that a novel calcium phosphate cement (CPC)-magnesium alloy composite scaffold would be applicable to reduce stress shielding and enable personalized treatment through structural surface modification techniques. Its biodegradable property might eliminate the need for secondary surgeries, while the products of degradation would synergistically promote bone healing. A modified surgical approach was suggested to minimize medullary cavity expansion, reduce joint and soft tissue trauma, and shorten recovery time. This concept may offer a novel therapeutic strategy for diaphyseal fractures to alleviate patients’ physiological, psychological, and financial burdens. In the future, the research directions may involve interface reinforcement, dynamic in vivo degradation-osteogenesis matching, and clinical translation validation.