Astaxanthin ameliorates Cr (VI) accumulation, antioxidant, digestive, apoptosis and inflammatory response

IF 2.1 4区环境科学与生态学 Q3 ECOLOGY

Regional Studies in Marine Science Pub Date : 2025-05-15 DOI:10.1016/j.rsma.2025.104240

Lei Zhao , Ying Zhang , Jie Yu , Yi-Han Liu , Zhi-Hao Cai , Mu-Yang Li , Ming Liu

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引用次数: 0

Abstract

Exposure to Cr (VI) can induce various adverse effects such as oxidative stress and inflammatory response in fish. Astaxanthin have been documented as a novel antioxidant and heavy metal antidote. This study was investigated potential protective effect of astaxanthin on Cr (VI) accumulation, antioxidant, digestive enzyme, glucocorticoid receptor (GR)-regulated inflammatory response and apoptosis in snakehead fish (Channa argus). In this study, 300 C. argus were randomly divided into three groups. The fish were exposed to waterborne Cr(VI) and/or dietary astaxanthin for 28 days. The results provided evidences that astaxanthin could inhibit Cr (VI) bioaccumulation, inflammatory response and apoptosis. Additionally, astaxanthin also exerted protective effects by increasing the activity of antioxidant, digestive enzymes and GR-related genes expression levels. Overall, our results suggest that administration of 100 mg/kg astaxanthin has the potential to combat Cr (VI) toxicity, antioxidant, digestive, anti-apoptosis.

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虾青素改善Cr （VI）积累、抗氧化、消化、细胞凋亡和炎症反应

暴露于铬（VI）可引起鱼类氧化应激和炎症反应等各种不良反应。虾青素是一种新型的抗氧化剂和重金属解毒剂。本研究旨在探讨虾青素对Cr （VI）积累、抗氧化、消化酶、糖皮质激素受体（GR）调控的炎症反应和细胞凋亡的潜在保护作用。在这项研究中，300 C。阿古斯被随机分为三组。将鱼暴露于水中Cr（VI）和/或饲料虾青素28天。结果表明虾青素可抑制Cr （VI）的生物积累、炎症反应和细胞凋亡。此外，虾青素还通过提高抗氧化酶、消化酶活性和gr相关基因表达水平发挥保护作用。综上所述，我们的研究结果表明，100 mg/kg虾青素具有抗Cr （VI）毒性、抗氧化、消化和抗凋亡的潜力。

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来源期刊

Regional Studies in Marine Science Agricultural and Biological Sciences-Ecology, Evolution, Behavior and Systematics

CiteScore

3.90

自引率

4.80%

发文量

336

审稿时长

69 days

期刊介绍： REGIONAL STUDIES IN MARINE SCIENCE will publish scientifically sound papers on regional aspects of maritime and marine resources in estuaries, coastal zones, continental shelf, the seas and oceans.