Copper-Catalyzed Chemoselective Hydrogenation of Unsaturated Bonds with Formic Acid/Formate as Hydrogen Donor.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-19 DOI:10.1021/acs.orglett.5c01372

Shumei Xia,Jiaoyu Peng,Shaolei Xie,Taoshan Xu,Lijuan Li,Xin Liu,Dawei Cao,Liang-Nian He,Chao-Jun Li

引用次数: 0

Abstract

A novel and sustainable strategy, using earth abundant Cu2O as catalyst and biorenewable HCOOH/HCOOK as hydrogen donor for the efficient hydrogenation of multiple unsaturated compounds, including internal and terminal alkynes, ketones, aldehydes, and imines, has been developed to access high-value chemicals with high chemoselectivity. This protocol features operation simplicity, wide substrate applicability, and only CO2 as a byproduct. Additionally, gram-scale experiments and the modification of biologically active molecules all exemplified the synthetic versatility of this protocol.

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以甲酸/甲酸酯为氢供体的铜催化不饱和键的化学选择性加氢反应。

利用地球上丰富的Cu2O作为催化剂，生物可再生的HCOOH/HCOOK作为氢供体，对多种不饱和化合物（包括内部和末端炔、酮、醛和亚胺）进行高效加氢，以获得具有高化学选择性的高价值化学品，这是一种新的可持续策略。该协议的特点是操作简单，广泛的底物适用性，并且只有二氧化碳作为副产品。此外，克级实验和生物活性分子的修饰都证明了该方案的合成通用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.