Drugs and patient's dissatisfaction reporting: From a disproportionality pharmacovigilance analysis to social pharmacology.

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY

Therapie Pub Date : 2025-05-01 DOI:10.1016/j.therap.2025.04.005

Jean-Louis Montastruc

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引用次数: 0

Abstract

Introduction: Patient satisfaction is a key element in medical practice. Few studies have investigated patient satisfaction or dissatisfaction with their drug treatment.

Method: Using the World Health Organization (WHO) global pharmacovigilance database, we investigated, through disproportionality analyses, potential associations between exposure to drugs and "patient dissatisfaction with treatment" reports. All reports of "patient dissatisfaction with treatment" in adults until 31/12/2024 were included.

Results/discussion: Results are expressed as reporting odds ratio (ROR). Among 506 reports, three quarters came from consumers, involving mainly women aged between 45 and 64. The main coreported term was drug inefficacy (before adverse drug reactions). The first anatomical therapeutic chemical (ATC) group was dermatological drugs (25.5%) followed by alimentary tract and metabolism (24.3%), nervous system (22.5%) drugs. A significant association was found with 22 drugs with the highest ROR values for plecanatide, efinaconazole and avatrombopag.

Conclusion: Despite its mandatory limitations (underreporting, selective reporting…), this study shows that pharmacovigilance data could help to understand some aspects of social pharmacology, here, patient dissatisfaction with their drug treatment.

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药物与患者不满报告：从不均衡药物警戒分析到社会药理学。

患者满意度是医疗实践的关键因素。很少有研究调查患者对药物治疗的满意度或不满意度。方法：利用世界卫生组织（WHO）全球药物警戒数据库，通过歧化分析，调查药物暴露与“患者对治疗不满意”报告之间的潜在关联。截至2024年12月31日，所有成人“患者对治疗不满意”的报告均被纳入。结果/讨论：结果以报告优势比（ROR）表示。在506份报告中，四分之三来自消费者，主要涉及年龄在45至64岁之间的女性。共同报告的主要术语为药物无效（药物不良反应前）。解剖治疗化学（ATC）组以皮肤类药物为主（25.5%），其次为消化道及代谢类药物（24.3%）、神经系统类药物（22.5%）。发现与22种药物有显著相关性，其中普莱那肽、艾非那康唑和阿瓦龙帕格的ROR值最高。结论：尽管存在强制性限制（少报、选择性报告等），但本研究表明，药物警戒数据可以帮助了解社会药理学的某些方面，例如患者对药物治疗的不满。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapie 医学-药学

CiteScore

3.50

自引率

7.70%

发文量

132

审稿时长

57 days

期刊介绍： Thérapie is a peer-reviewed journal devoted to Clinical Pharmacology, Therapeutics, Pharmacokinetics, Pharmacovigilance, Addictovigilance, Social Pharmacology, Pharmacoepidemiology, Pharmacoeconomics and Evidence-Based-Medicine. Thérapie publishes in French or in English original articles, general reviews, letters to the editor reporting original findings, correspondence relating to articles or letters published in the Journal, short articles, editorials on up-to-date topics, Pharmacovigilance or Addictovigilance reports that follow the French "guidelines" concerning good practice in pharmacovigilance publications. The journal also publishes thematic issues on topical subject. The journal is indexed in the main international data bases and notably in: Biosis Previews/Biological Abstracts, Embase/Excerpta Medica, Medline/Index Medicus, Science Citation Index.