Investigating the Effect of Solvent Polarity Environment Differences in Electrolyte and non-Electrolyte Systems.

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Journal of pharmaceutical sciences Pub Date : 2025-05-14 DOI:10.1016/j.xphs.2025.103836

Valeria Briceida Tellez Gallego, Kate Sorg, Rodolfo Pinal

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引用次数: 0

Abstract

To address the knowledge gap regarding the polarity of excipient solutions and the impact on biologically relevant systems, a comprehensive exploration of the polarity of solutions is essential. This study explores the solvatochromic response of Reichardt's dye to solvent polarity in aqueous solutions, focusing on structurally similar electrolytes and non-electrolytes at concentrations typically used in pharmaceutical formulations. UV absorbance measurements demonstrated sensitivity to subtle structural differences, such as counterion variations or glycosidic bonds. Here, chloride salts and disaccharides were analyzed and notable polarity differences between similar systems were found. Additionally, unexpected similarities between sodium chloride and trehalose were observed. This investigation underscores the potential of readily accessible solvent polarity and solvatochromic studies to deepen the understanding of aqueous solutions and extend their application to pharmaceutical excipients and their roles in protein formulation.

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研究电解质和非电解质体系中溶剂极性环境差异的影响。

为了解决关于赋形剂溶液极性和对生物相关系统的影响的知识差距，对溶液极性的全面探索是必不可少的。本研究探讨了Reichardt染料在水溶液中对溶剂极性的溶剂变色反应，重点关注结构相似的电解质和药物配方中通常使用浓度的非电解质。紫外吸收测量显示了对细微结构差异的敏感性，如反离子变化或糖苷键。本文对氯盐和双糖进行了分析，发现相似体系之间存在显著的极性差异。此外，观察到氯化钠和海藻糖之间意想不到的相似性。这项研究强调了易于获得的溶剂极性和溶剂致变色研究的潜力，以加深对水溶液的理解，并将其应用于药用辅料及其在蛋白质配方中的作用。

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来源期刊

Journal of pharmaceutical sciences 医学-化学综合

CiteScore

7.30

自引率

13.20%

发文量

367

审稿时长

33 days

期刊介绍： The Journal of Pharmaceutical Sciences will publish original research papers, original research notes, invited topical reviews (including Minireviews), and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.