Correlation of serum biomarkers with clinicoradiological assessments in patients with moderate and severe traumatic brain injury.

IF 3.5 2区 医学 Q1 CLINICAL NEUROLOGY
Jamiu Ayodele Adebiyi, Ayodeji Salman Yusuf, Muhammad Raji Mahmud, Nabilah Datti Abubakar, Alvan-Emeka K Ukachukwu
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引用次数: 0

Abstract

Objective: Despite advancements in traumatic brain injury (TBI) management and the development of standardized care guidelines, mortality and morbidity rates remain high. Current diagnostic and prognostic tools are limited, particularly in resource-constrained settings. This study investigated the potential role of serum biomarkers, including glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and S100β protein, in assessing the clinical severity and outcomes of patients with moderate and severe TBI in a Nigerian trauma center.

Methods: This prospective, single-center study included 44 patients with moderate and severe TBI admitted to the National Hospital Abuja, Nigeria, from November 5, 2019, to November 4, 2020. Clinical and radiological data were documented, and serum levels of GFAP, NSE, and S100β protein were measured at admission, as well as 3 and 7 days postinjury, using enzyme-linked immunosorbent assay kits. Treatment outcomes were assessed using the Glasgow Outcome Scale at 3 months post-TBI.

Results: At admission, mean serum levels of GFAP (1.85 ± 1.12 ng/ml), NSE (14.25 ± 2.77 ng/ml), and S100β protein (0.60 ± 0.20 ng/ml) were elevated beyond normal reference values. Serum levels were significantly higher in patients with severe TBI compared with those with moderate TBI (p < 0.05). An inverse relationship was observed between serum biomarker levels and Glasgow Coma Scale scores, with patients experiencing unfavorable outcomes exhibiting higher biomarker levels. Additionally, GFAP and NSE showed an inverse correlation with the Rotterdam CT score within 24 hours of admission, while S100β protein demonstrated a direct correlation. The area under the curve for GFAP was the highest at 0.828, compared with 0.759 for NSE and 0.750 for S100β protein.

Conclusions: Among the biomarkers studied, S100β protein showed a superior correlation with radiological findings, whereas GFAP demonstrated the most reliable predictive ability for prognosticating outcomes in patients with moderate and severe TBI.

中重度颅脑损伤患者血清生物标志物与临床放射学评价的相关性。
目的:尽管创伤性脑损伤(TBI)的管理和标准化护理指南的发展取得了进展,但死亡率和发病率仍然很高。目前的诊断和预后工具有限,特别是在资源有限的情况下。这项研究调查了血清生物标志物的潜在作用,包括胶质纤维酸性蛋白(GFAP)、神经元特异性烯醇化酶(NSE)和S100β蛋白,在尼日利亚创伤中心评估中度和重度TBI患者的临床严重程度和预后。方法:这项前瞻性单中心研究纳入了2019年11月5日至2020年11月4日在尼日利亚阿布贾国家医院住院的44例中重度TBI患者。记录临床和放射学资料,并使用酶联免疫吸附测定试剂盒在入院时以及损伤后3和7天测定血清GFAP、NSE和S100β蛋白水平。在tbi后3个月使用格拉斯哥结果量表评估治疗结果。结果:入院时血清GFAP(1.85±1.12 ng/ml)、NSE(14.25±2.77 ng/ml)、S100β蛋白(0.60±0.20 ng/ml)均高于正常参考值。重型颅脑损伤患者血清水平明显高于中度颅脑损伤患者(p < 0.05)。血清生物标志物水平与格拉斯哥昏迷量表评分呈反比关系,出现不良结局的患者表现出较高的生物标志物水平。此外,GFAP和NSE与入院24小时内的Rotterdam CT评分呈负相关,而S100β蛋白与入院24小时内的Rotterdam CT评分呈直接相关。GFAP的曲线下面积最大,为0.828,NSE为0.759,S100β蛋白为0.750。结论:在研究的生物标志物中,S100β蛋白显示出与放射学表现的优越相关性,而GFAP显示出对中度和重度TBI患者预后的最可靠预测能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of neurosurgery
Journal of neurosurgery 医学-临床神经学
CiteScore
7.20
自引率
7.30%
发文量
1003
审稿时长
1 months
期刊介绍: The Journal of Neurosurgery, Journal of Neurosurgery: Spine, Journal of Neurosurgery: Pediatrics, and Neurosurgical Focus are devoted to the publication of original works relating primarily to neurosurgery, including studies in clinical neurophysiology, organic neurology, ophthalmology, radiology, pathology, and molecular biology. The Editors and Editorial Boards encourage submission of clinical and laboratory studies. Other manuscripts accepted for review include technical notes on instruments or equipment that are innovative or useful to clinicians and researchers in the field of neuroscience; papers describing unusual cases; manuscripts on historical persons or events related to neurosurgery; and in Neurosurgical Focus, occasional reviews. Letters to the Editor commenting on articles recently published in the Journal of Neurosurgery, Journal of Neurosurgery: Spine, and Journal of Neurosurgery: Pediatrics are welcome.
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