Fitbit-measured physical activity is inversely associated with incident atrial fibrillation among All of Us participants.

IF 3.7 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal Pub Date : 2025-05-14 DOI:10.1016/j.ahj.2025.05.003

Souptik Barua, Dhairya Upadhyay, Aditya Surapaneni, Morgan Grams, Lior Jankelson, Sean Heffron

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引用次数: 0

Abstract

Background: Individuals who report meeting weekly moderate to vigorous physical activity (MVPA) guidelines have lower risk of atrial fibrillation (AF). However existing studies have relied on subjective questionnaires or short-duration (<1 week) objective assessments using accelerometry. The objective of this research was to investigate an association between MVPA levels and the incidence of AF, utilizing long-term, free-living accelerometry data.

Methods: 1-year Fitbit data, in addition to survey and electronic health record (EHR) data, were extracted from the NIH All of Us (AoU) research database. Cox proportional hazards regression was used to model the association of average MVPA and incident AF over a five-year follow-up period.

Results: 15570 AoU participants were included (52±16 years, 71% female, 79% White, BMI 28.9±5.0 kg/m², 41±12 complete weeks of Fitbit wear). 97 individuals (0.6%) experienced incident AF in the five-year follow-up period. Every additional hour of MVPA was associated with 8% lower AF risk (HR = 0.92 [0.86,0.99], p=0.02). In a subset of 10533 participants with genomic data, this association persisted after adjustment for AF genetic risk score.

Conclusions: Higher amounts of objectively measured MVPA, measured using free-living, long-term accelerometry data, were inversely associated with risk of incident AF, independent of clinical and genetic risk factors.

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在我们所有的参与者中，fitbit测量的身体活动与房颤的发生率呈负相关。

背景：每周参加中度至剧烈体育活动（MVPA）指南的人患房颤（AF）的风险较低。然而，现有的研究依赖于主观问卷或短时间(方法：1年的Fitbit数据，以及调查和电子健康记录（EHR）数据，从NIH All of Us （AoU）研究数据库中提取。采用Cox比例风险回归对5年随访期间平均MVPA和AF事件的关联进行建模。结果：纳入15570名AoU参与者（52±16岁，71%女性，79%白人，BMI 28.9±5.0 kg/m2，佩戴Fitbit 41±12周）。97人（0.6%）在5年随访期间发生房颤。MVPA每增加1小时，房颤风险降低8% （HR = 0.92 [0.86,0.99],p=0.02）。在10533名具有基因组数据的参与者中，这种关联在调整房颤遗传风险评分后仍然存在。结论：较高的客观测量MVPA，使用自由生活，长期加速度计数据测量，与房颤发生风险负相关，独立于临床和遗传风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American heart journal 医学-心血管系统

CiteScore

8.20

自引率

2.10%

发文量

214

审稿时长

38 days

期刊介绍： The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.