Association between haemoglobin A1c level and hip fracture risk in type 2 diabetes patients: A systematic review and meta-analysis

Q2 Medicine

Journal of Clinical Orthopaedics and Trauma Pub Date : 2025-05-10 DOI:10.1016/j.jcot.2025.103040

Mohammad Arshad Ikram , Justin Vijay Gnanou , Chin Chai Chong , Nisar Ahmed , Shobna Sai Letchumenan , Zairul-Nizam Zainol Fithri

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引用次数: 0

Abstract

Background

Hip fractures are prevalent in the elderly. Diabetes complication includes osteoporosis, which raises the possibility of hip fractures in an elderly population with type 2 diabetes mellitus. The purpose of this Meta-analysis is to determine whether long-term glycaemic management, as measured by HbA1c in patients with diabetes mellitus, is associated with a lower incidence of hip fractures.

Methods

The study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-analyses 2020 (PRISMA) guidelines. We searched PubMed, Ovid, and ScienceDirect, and did a manual search of the reference lists of identified studies for published data on the association between hip fractures and glycaemic control. This systematic review was registered with PROSPERO with a Registration number: CRD42021260328. All eligible articles were included, and a meta-analysis on the comparison between HbA1c values above 6.5 and below 6.5 and between HbA1c values above 6.0 and below 6.0 in patients above 65 years with diabetes mellitus will be done by using a Forest plot. Odds Ratio (OR) and 95 % confidence intervals (CIs) will be calculated as summary statistics for dichotomous outcomes.

Results

Thirty-seven relevant articles were identified in the initial search, and four of these studies met the inclusion criteria for this systematic review and meta-analysis.

Conclusion

Our study suggests that hip fractures are more common in the elderly diabetic population when haemoglobin A1c levels exceed 6.5 %.

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2型糖尿病患者血红蛋白A1c水平与髋部骨折风险的关系：一项系统综述和荟萃分析

背景：髋部骨折在老年人中很常见。糖尿病并发症包括骨质疏松症，这增加了老年2型糖尿病患者髋部骨折的可能性。本荟萃分析的目的是确定糖尿病患者的糖化血红蛋白（HbA1c）测量的长期血糖管理是否与髋部骨折发生率降低有关。方法本研究按照2020年系统评价和荟萃分析首选报告项目（PRISMA）指南进行。我们检索了PubMed、Ovid和ScienceDirect，并手工检索了已确认研究的参考文献列表，以获取髋骨骨折与血糖控制之间的相关数据。本系统评价已在PROSPERO注册，注册号为CRD42021260328。纳入所有符合条件的文章，并采用Forest图对65岁以上糖尿病患者HbA1c值高于6.5与低于6.5、高于6.0与低于6.0的HbA1c值进行meta分析。比值比（OR）和95%置信区间（ci）将作为二分类结果的汇总统计。结果在最初的检索中发现了37篇相关文章，其中4篇研究符合本系统评价和荟萃分析的纳入标准。结论我们的研究表明，当老年糖尿病患者血红蛋白A1c水平超过6.5%时，髋部骨折更为常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Orthopaedics and Trauma Medicine-Orthopedics and Sports Medicine

CiteScore

4.30

自引率

0.00%

发文量

181

审稿时长

92 days

期刊介绍： Journal of Clinical Orthopaedics and Trauma (JCOT) aims to provide its readers with the latest clinical and basic research, and informed opinions that shape today''s orthopedic practice, thereby providing an opportunity to practice evidence-based medicine. With contributions from leading clinicians and researchers around the world, we aim to be the premier journal providing an international perspective advancing knowledge of the musculoskeletal system. JCOT publishes content of value to both general orthopedic practitioners and specialists on all aspects of musculoskeletal research, diagnoses, and treatment. We accept following types of articles: • Original articles focusing on current clinical issues. • Review articles with learning value for professionals as well as students. • Research articles providing the latest in basic biological or engineering research on musculoskeletal diseases. • Regular columns by experts discussing issues affecting the field of orthopedics. • "Symposia" devoted to a single topic offering the general reader an overview of a field, but providing the specialist current in-depth information. • Video of any orthopedic surgery which is innovative and adds to present concepts. • Articles emphasizing or demonstrating a new clinical sign in the art of patient examination is also considered for publication. Contributions from anywhere in the world are welcome and considered on their merits.