Identification and Structural Elucidation of a Novel Pyrrolidinophenone-Based Designer Drug on the Illicit Market: α-BPVP

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2025-05-07 DOI:10.1021/acs.chemrestox.5c0006810.1021/acs.chemrestox.5c00068

Sara Casati, Roberta F. Bergamaschi, Riccardo Primavera, Alessandro Ravelli, Ivana Lavota, Alessio Battistini, Gabriella Roda, Chiara Ciccarelli, Claudio Guidotti and Paola Rota*,

引用次数: 0

Abstract

The identification of a new psychoactive substances (NPS) with a cathinone structure and a biphenyl substituent, found in seized powder from the black market, is here reported. By combining analytical techniques, including 1D and 2D NMR and HRMS, the compound was identified as 1-([1,1′-biphenyl]-4-yl)-2-(pyrrolidin-1-yl)pentan-1-one (α-BPVP), an α-pyrrolidinopentiophenone (α-PVP) analogue featuring a biphenyl group instead of the phenyl ring. This previously unreported molecule raises urgent legal and public health concerns, which warrants further toxicological investigation.

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非法市场上一种新型吡咯烷酮类设计药物α-BPVP的鉴定和结构解析

在黑市缴获的粉末中发现了一种新的具有卡西酮结构和联苯取代基的精神活性物质（NPS）。结合一维、二维NMR和HRMS等分析技术，鉴定该化合物为1-（[1,1 ' -联苯]-4-基）-2-（吡咯烷-1-基）戊烷-1-酮（α-PVP）类似物，以联苯取代苯基环。这种先前未报道的分子引起了紧急的法律和公共卫生问题，需要进一步的毒理学调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.