Daily Impact of Medical Cannabis on Anxiety and Sleep Quality in Older Adults.

IF 2.7 4区 医学 Q2 PSYCHIATRY
Madison Maynard, Robert D Dvorak, Daniel Paulson, Emily K Burr, Quinn Allen, Nichole R Lighthall, Apollonia E Lysandrou
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Abstract

Objective: Older adults represent the fastest growing demographic of cannabis users, and they endorse cannabis use for a variety of reasons including modulation of chronic pain, mental health symptoms, and sleep concerns. However, current evidence leaves questions of efficacy unanswered among these groups. Goals of the present study were to examine the hypothesis that medical cannabis (MC) use will, at the daily level, predict lower pain, depression, anxiety, and improved sleep.

Method: A final sample of 106 MC users were recruited nationwide (ages 55-74, 66.67% female, 82.86% white). A fully within-subject multilevel structural equation model was conducted with use patterns and symptomology broken into four temporal epochs. MC use, operationalized as subjective intoxication (Epoch 1), averaged across the day was used to predict subsequent pain, anxiety, and depression levels (Epoch 2), which were then used to predict sleep that night (Epoch 3), then subsequent pain, anxiety, and depression the following day (Epoch 4) prior to initiation of MC use.Results: Subjective intoxication predicted lower post-use pain, anxiety, and depression. Subjective intoxication is related to lower anxiety and better sleep the following night.

Conclusions: These findings provide evidence of momentary improvements in pain, anxiety, depression, and indirect benefits for sleep quality. In combination with other findings, the results advance our understanding of the efficacy and limitations of MC among older adults. Findings are limited by MC measurement and sample homogeneity (primarily White, non-Hispanic female). Future research should seek to further measurement of use and corresponding effects and examine expectancy effects in aging clinical populations.

医用大麻对老年人焦虑和睡眠质量的日常影响。
目的:老年人是大麻使用者中增长最快的群体,他们出于多种原因支持使用大麻,包括缓解慢性疼痛、心理健康症状和睡眠问题。然而,目前的证据对这些群体的有效性提出了疑问。本研究的目的是检验假设医用大麻(MC)的使用将在日常水平上预测较低的疼痛,抑郁,焦虑和改善睡眠。方法:最终在全国范围内招募106名MC用户(年龄55-74岁,女性66.67%,白人82.86%)。一个完全在主体内的多层次结构方程模型进行了使用模式和症状分为四个时间时期。MC的使用,被操作为主观中毒(阶段1),全天平均用于预测随后的疼痛、焦虑和抑郁水平(阶段2),然后用于预测当晚的睡眠(阶段3),然后在开始使用MC之前的第二天(阶段4)随后的疼痛、焦虑和抑郁。结果:主观中毒预测较低的使用后疼痛、焦虑和抑郁。主观中毒与第二天晚上较低的焦虑和较好的睡眠有关。结论:这些发现为疼痛、焦虑、抑郁的短暂改善提供了证据,并间接改善了睡眠质量。结合其他研究结果,这些结果促进了我们对老年人MC的疗效和局限性的理解。研究结果受到MC测量和样本同质性(主要是白人,非西班牙裔女性)的限制。未来的研究应寻求进一步测量使用和相应的效果,并检查老年临床人群的预期效应。
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来源期刊
CiteScore
2.70
自引率
0.00%
发文量
48
审稿时长
>12 weeks
期刊介绍: Internationally recognized, Psychiatry has responded to rapid research advances in psychiatry, psychology, neuroscience, trauma, and psychopathology. Increasingly, studies in these areas are being placed in the context of human development across the lifespan, and the multiple systems that influence individual functioning. This journal provides broadly applicable and effective strategies for dealing with the major unsolved problems in the field.
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