Transdifferentiation of Hairy Cell Leukemia to Lytic and Mass-Producing Histiocytic Sarcoma: A Novel Head and Neck Example and Review of the Literature.

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2025-05-15 DOI:10.1007/s12105-025-01780-4

Austin J Davies, Parnaz Daneshpajouhnejad, Mugdha Patwardhan, Zaizhen Xu, Darren P Cox

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引用次数: 0

Abstract

Background: Transdifferentiation of hairy cell leukemia to histiocytic sarcoma (HS) has not been previously reported in the head and neck. Given the rarity of HS, it can pose a challenge to diagnose this aggressive malignancy.

Case presentation: A 93-year-old male with a complex medical history presented with symptomatic and mobile lower anterior teeth. No intraoral growth mass was present initially and radiographic examination showed a radiolucent lesion in the anterior mandible. An incisional biopsy under local anesthesia was performed and histopathologic examination revealed a malignant sarcoma which upon further clinical, immunohistochemical, and molecular workup, confirmed the diagnosis.

Diagnosis: Initial histopathologic evaluation of the biopsy rendered a provisional diagnosis of undifferentiated pleomorphic sarcoma. The case was referred to a tertiary care center for complete medical workup and additional ancillary studies where it was definitively diagnosed as a HS. The patient passed away a month after this HS diagnosis.

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毛细胞白血病转分化为溶解性和大量产生的组织细胞肉瘤：一个新的头颈部例子和文献综述。

背景：毛细胞白血病向组织细胞肉瘤（HS）的转分化在头颈部尚未见报道。鉴于HS的罕见性，它可以提出一个挑战，以诊断这种侵袭性恶性肿瘤。病例介绍：93岁男性，病史复杂，下门牙有症状，可移动。最初没有口腔内生长肿块，x线检查显示前下颌有一个透光病变。在局部麻醉下行切口活检，组织病理学检查显示为恶性肉瘤，经过进一步的临床、免疫组织化学和分子检查，证实了诊断。诊断：活检的初步组织病理学评估初步诊断为未分化多形性肉瘤。该病例被转诊到三级保健中心进行完整的医疗检查和额外的辅助研究，最终被诊断为HS。这个病人在这个HS诊断后一个月去世了。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.