Oral and Maxillofacial Low-Grade Myofibroblastic Sarcoma: A Systematic Review.

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2025-05-15 DOI:10.1007/s12105-025-01783-1

Daniela Giraldo-Roldan, João Paulo Gonçalves De Paiva, Ana Luiza Oliveira Corrêa Roza, Brendo Vinicius Rodrigues Louredo, Éder Gerardo Santos-Leite, Pablo Agustin Vargas

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引用次数: 0

Abstract

Background: This systematic review (SR) aimed to summarize the clinical, histopathological, and immunohistochemical features of low-grade myofibroblastic sarcoma (LGMS) in the oral and maxillofacial region (OMR), as well as treatment protocols, recurrence, follow-up, and metastasis rates. It follows PRISMA 2022 guidelines and is registered in PROSPERO (CRD42023409758).

Methods: An electronic search included PubMed, EMBASE, Scopus, Web of Science, LILACS, Google Scholar, and ProQuest databases, and bias risk was assessed using the Joanna Briggs Institute tool. Statistical analyses, including Fisher's and Chi-Squared tests, were conducted to explore associations between clinical variables, and survival analysis was performed using the Kaplan-Meier method.

Results: Forty-three studies covering 78 cases were included. LGMS showed a slight female predominance (51.28%) and an average patient age of 35.35 years. The most affected sites were the mandible (29.4%), maxilla (19.23%), and tongue (15.38%). Clinical presentations included masses (30.76%), tumors (26.92%), and swelling (12.82%), with symptom duration ranging from 1 week to 30 months. Surgery alone was the primary treatment (60.25%), with recurrence in 20.51% and metastasis in 5.12% of cases. One-year and 5-year overall survival rates were 92.6% and 71.8%, respectively. Surgery as the sole treatment was significantly associated with a lower metastasis rate (p = 0.005).

Conclusion: Our findings highlighted the importance of considering LGMS in differential diagnoses of myofibroblastic lesions and underscored the need for a comprehensive immunohistochemical analysis. Complete surgical excision remains the preferred treatment, though long-term follow-up is needed to better understand recurrence and metastasis risks.

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口腔颌面部低级别肌成纤维细胞肉瘤：系统综述。

背景：本系统综述（SR）旨在总结口腔颌面区（OMR）低级别肌成纤维细胞肉瘤（LGMS）的临床、组织病理学和免疫组织化学特征，以及治疗方案、复发、随访和转移率。它遵循PRISMA 2022指南，并在PROSPERO注册（CRD42023409758）。方法：电子检索PubMed、EMBASE、Scopus、Web of Science、LILACS、谷歌Scholar、ProQuest等数据库，采用Joanna Briggs Institute工具评估偏倚风险。统计分析，包括Fisher检验和Chi-Squared检验，以探讨临床变量之间的关联，并使用Kaplan-Meier法进行生存分析。结果：纳入43项研究，78例。LGMS患者以女性为主（51.28%），平均年龄35.35岁。其中，上颌（19.23%）、舌部（15.38%）和下颌骨（29.4%）最为常见。临床表现为包块（30.76%）、肿瘤（26.92%）、肿胀（12.82%），症状持续时间为1周至30个月。单纯手术为主要治疗方法（60.25%），复发20.51%，转移5.12%。1年和5年总生存率分别为92.6%和71.8%。手术作为唯一的治疗方法与较低的转移率显著相关（p = 0.005）。结论：我们的研究结果强调了在肌成纤维细胞病变的鉴别诊断中考虑LGMS的重要性，并强调了全面的免疫组织化学分析的必要性。完全手术切除仍然是首选的治疗方法，但需要长期随访以更好地了解复发和转移的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.