"Is Intravascular Ultrasound-guided Angiography a Better Choice than Angiography Alone for Patients with Acute Coronary Syndrome and Coronary Artery Disease? Unveiling the Efficacy and Safety of This Modern Imaging Method: A Systematic Review and Meta-Analysis."
Khaled M Harmouch, Mobeen Haider, Mohammad Hamza, Prakash Upreti, Yasemin Bahar, Mustafa Turkmani, Tea Rrapo, Nomesh Kumar, Manoj Kumar, Wasif Safdar, Yasar Sattar, Fnu Zafrullah, Abu Mhafouz, M Chadi Alraies
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引用次数: 0
Abstract
Introduction: Coronary angiography has been an established standard for over six decades for percutaneous coronary interventions (PCI), but its role is limited to assessing vascular lumen and anterograde flow. In the 1980s, intravascular ultrasonography (IVUS) gained traction in interventional cardiology for its advantages over angiography. Despite its precise evaluation of plaque burden and vessel wall structure for optimizing stent implantation, the literature reports varying outcomes on the efficacy and safety of IVUS-guided angiography in patients presenting with acute coronary syndrome (ACS) or coronary artery disease (CAD). To address this discrepancy, we conducted a comprehensive systematic review and meta-analysis to assess the efficacy and safety of utilizing IVUS vs angiography alone for PCI in these groups of patients.
Methods: We conducted a comprehensive systematic review and meta-analysis to assess the efficacy and safety of IVUS-guided angiography in these patients. Electronic databases were searched, and 25 studies were included. Inclusion criteria were: 1) patients aged > 18 years, 2) patients with ACS or CAD undergoing IVUS-guided PCI or angiography-guided PCI, and 3) Randomized Clinical Trials (RCTs). Exclusion criteria comprised observational, non-randomized studies, case reports, clinical spotlights, and review articles. Studied outcomes included all-cause mortality, cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), need for coronary artery bypass graft (CABG), and stent thrombosis (ST).
Results: Compared to angiography alone, IVUS-guided PCI demonstrated a significant reduction in cardiac death, TLR, and ST regardless of the follow-up period. No significant difference was observed between the two groups concerning all-cause mortality, and MI regardless of the follow-up period, and the need for CABG at one-year follow-up.
Conclusion: Compared to angiography-guided PCI, IVUS-guided PCI is associated with a lower incidence of cardiac death, TLR, and ST.
期刊介绍：
Critical Pathways in Cardiology provides a single source for the diagnostic and therapeutic protocols in use at hospitals worldwide for patients with cardiac disorders. The Journal presents critical pathways for specific diagnoses—complete with evidence-based rationales—and also publishes studies of these protocols" effectiveness.
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