Highlights of the 14th International Bordetella Symposium.

IF 3.7 2区生物学 Q2 MICROBIOLOGY

mSphere Pub Date : 2025-05-16 DOI:10.1128/msphere.00189-25

Kevin Munoz Navarrete, Kathryn M Edwards, Kingston H G Mills, Jana Kamanová, María Eugenia Rodriguez, Andrew Gorringe, Andrew Preston, Beate Kampmann, Monica C Gestal, Eric T Harvill, Purnima Dubey, Dimitri A Diavatopoulos, Seema Mattoo, Karen M Scanlon, Camille Locht, Peter Sebo

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Abstract

Pertussis, or whooping cough, is a highly contagious and acute respiratory illness caused primarily by the gram-negative coccobacillus Bordetella pertussis. Despite near-universal vaccination, pertussis remains one of the least-controlled vaccine-preventable infectious diseases. Since 2023, pertussis incidence has been rising, and widespread pertussis outbreaks have resurged in many countries. In response to these emerging challenges, almost 300 experts from institutions across 24 countries convened at the 14th International Bordetella Symposium in Prague, Czech Republic, from 24 to 28 June 2024 to discuss pertussis epidemiology and research and strategies to mitigate the global pertussis burden. We present here the highlights of the symposium, comprising epidemiological and clinical aspects of Bordetella infections, results of clinical trials of pertussis vaccination in pregnant women and effectiveness of maternal vaccination in protecting newborn infants in Africa and Europe, the controlled human infection model (CHIM), and the latest insights into the biology, immunology, and pathogenesis of B. pertussis infection.

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第十四届博德泰拉国际研讨会的亮点。

百日咳或百日咳是一种高度传染性的急性呼吸道疾病，主要由革兰氏阴性的百日咳杆菌引起。尽管几乎普遍接种了疫苗，百日咳仍然是控制最少的疫苗可预防传染病之一。自2023年以来，百日咳发病率一直在上升，在许多国家又出现了大范围的百日咳疫情。为了应对这些新出现的挑战，来自24个国家机构的近300名专家于2024年6月24日至28日在捷克共和国布拉格召开了第14届国际博德泰拉研讨会，讨论百日咳流行病学和研究以及减轻全球百日咳负担的战略。我们在此介绍研讨会的重点，包括博德泰拉感染的流行病学和临床方面，在非洲和欧洲，孕妇接种百日咳疫苗的临床试验结果和母亲接种百日咳疫苗保护新生儿的有效性，控制人类感染模型（CHIM），以及百日咳感染的生物学、免疫学和发病机制的最新见解。

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来源期刊

mSphere Immunology and Microbiology-Microbiology

CiteScore

8.50

自引率

2.10%

发文量

192

审稿时长

11 weeks

期刊介绍： mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.