Mengyu Zhong, Jian Zhu, Bohan Zhang, Hui Shen, Hongxia Li, Yuxiao Tang, Shuang Nie, Fengfeng Mo
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引用次数: 0
Abstract
Abnormal acceleration induced motion sickness (MS) and elevated blood glucose levels, showing obviously cognitive impairments. The mechanism of cognitive impairment caused by MS is still unclear. Here, blood metabolite detection, insulin level regulators, stress hormones, cytokines and MS assessment were conducted for the population and MS model rats, correlation analysis of motion sickness index (MSI) and above factors were conducted by correlation analysis. We found glucose after acceleration was positively correlated with Graybiel's score. Insulin and leptin levels decreased, while ghrelin level increased after acceleration in both human and rat groups. We injected insulin level regulators into rats before being exposed to acceleration, the results showed that MSI of the insulin group (INS) was significantly lower than rotation group (ROT), streptozotocin group (STZ) and streptozotocin & insulin group (SINS). MSI in STZ was higher than ROT and INS. Rats injected with ghrelin showed higher MSI than the control group and ghrelin antagonist group. Acceleration stimulation induced phosphorylation of insulin receptor substrate 1 (IRS1) and expression of synaptic protein in hippocampus. We also found that the insulin microinjection into hippocampus prevented MS symptoms and cognitive ability as measured by the MSI, the Open Field Test, the T-maze, and the Morris water maze. Our study indicates that insulin and insulin level regulators can affect MS symptoms and cognitive ability.
异常加速引起的运动病(MS)和血糖水平升高,表现出明显的认知障碍。多发性硬化症引起认知障碍的机制尚不清楚。本研究对人群和MS模型大鼠进行血液代谢物检测、胰岛素水平调节因子、应激激素、细胞因子及MS评估,通过相关分析对晕动病指数(MSI)与上述因素进行相关性分析。我们发现加速后的葡萄糖与Graybiel的评分呈正相关。在人类和大鼠组中,胰岛素和瘦素水平在加速后下降,而胃促生长素水平升高。我们在加速暴露前给大鼠注射胰岛素水平调节剂,结果显示胰岛素组(INS)的MSI显著低于旋转组(ROT)、链脲佐菌素组(STZ)和链脲佐菌素+胰岛素组(SINS)。STZ的MSI高于ROT和INS。注射胃饥饿素的大鼠MSI高于对照组和胃饥饿素拮抗剂组。加速刺激诱导海马胰岛素受体底物1 (IRS1)磷酸化和突触蛋白表达。通过MSI、Open Field Test、t迷宫和Morris水迷宫测量,我们还发现海马体微量注射胰岛素可以预防MS症状和认知能力。我们的研究表明胰岛素和胰岛素水平调节因子可以影响MS症状和认知能力。
期刊介绍:
Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on all metabolic brain disease, including both human and animal studies. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to physicians, neuroscientists, internists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of metabolic brain disorders.