Phenol as a breath marker for hemodialysis of chronic kidney disease patients.

IF 3.7 4区医学 Q1 BIOCHEMICAL RESEARCH METHODS

Journal of breath research Pub Date : 2025-05-27 DOI:10.1088/1752-7163/add958

Isabell Eickel, Anne-Christine Zygmunt, Frank Streit, Björn Tampe, Nils Kunze-Szikszay, Thorsten Perl

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引用次数: 0

Abstract

We aimed to identify biomarkers in breath analysis with multicapillary column-ion mobility spectrometry (MCC-IMS) to monitor the haemodialysis for chronic kidney disease (CKD) patients fast and non-invasive. Six patients' breath was analyzed via MCC-IMS before and after dialysis and compared to blood plasma samples analyzed via ultra performance liquid chromatography-fluorescence detector for potential renal failure biomarkers. Additionally, breath from six healthy control persons was analyzed. Phenol was found as a breath marker for CKD. For three patients the phenol concentration in breath and plasma was elevated before and decreased during dialysis and reached values in the range of healthy control persons. The peak-intensity of phenol-monomer peaks ofP01-P04 was reduced from an average of 16.58 (5.42-27.28) a.U. to 7.03 (0.00-13.65) a.U., which is a reduction by 42.51 (-10.55-100.00) %. The control group has an average peak-intensity of 8.50 (5.00-12.00) a.U. This study shows that the measurement of phenol via breath analysis could be used to monitor the haemodialysis for CKD-patients and might also be usable for the calculation of haemodialysis dose in the future.The study is registered in the German Clinical Trials Register under number DRKS00029679.

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苯酚作为慢性肾病患者血液透析的呼吸标志物。

背景：我们旨在利用MCC-IMS识别呼吸分析中的生物标志物，以快速、无创地监测CKD患者的血液透析。材料与方法：通过MCC-IMS分析6例患者透析前后的呼吸，并与UPLC-FLD分析的血浆样本进行比较，以寻找潜在的肾功能衰竭生物标志物。此外，还分析了6名健康对照者的呼吸。结果：苯酚是CKD的呼吸标志物。3例患者呼吸和血浆中酚浓度在透析前升高，透析期间降低，达到健康对照范围。P01 ~ P04的酚单体峰强度由平均16.58 (5.42 27.28)a.U降至7.03 (0.00 13.65)a.U，降低了42.51(-10.55 ~ 100.00)%。对照组平均峰值强度为8.50 (5.00 - 12.00)a.U。结论：本研究表明通过呼吸分析测量苯酚可用于ckd患者血液透析的监测，也可用于将来血液透析剂量的计算。该研究已在德国临床试验注册中心注册，编号为DRKS00029679。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of breath research BIOCHEMICAL RESEARCH METHODS-RESPIRATORY SYSTEM

CiteScore

7.60

自引率

21.10%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics. Typical areas of interest include: Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research. Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments. Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway. Cellular and molecular level in vitro studies. Clinical, pharmacological and forensic applications. Mathematical, statistical and graphical data interpretation.