Melanocytic neoplasm with novel EPS15:BRAF fusion and congenital features.

IF 2.7 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2025-05-13 DOI:10.1016/j.humpath.2025.105790

Shruti Agrawal, Ruifeng Guo

引用次数: 0

Abstract

This case highlights a report of a melanocytic lesion with a novel EPS15::BRAF fusion with distinct histopathologic features from Spitzoid neoplasm. This case broadens the morphologic spectrum of BRAF fused lesions to include congenital-type nevoid melanocytic lesions. Further follow up information is needed to better understand the clinical prognosis of melanocytic neoplasms harboring this novel fusion.

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黑色素细胞肿瘤与新型EPS15:BRAF融合和先天性特征。

本病例报告了一种新的EPS15::BRAF融合的黑素细胞病变，具有与Spitzoid肿瘤不同的组织病理特征。本病例拓宽了BRAF融合病变的形态学谱，包括先天性痣样黑素细胞病变。为了更好地了解这种新型融合的黑素细胞肿瘤的临床预后，需要进一步的随访信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.