Real-World Evidence for Baricitinib in the Treatment of Atopic Dermatitis and Alopecia Areata: Systematic Literature Review 2020-2023.

IF 3.5 3区 医学 Q1 DERMATOLOGY
Dermatology and Therapy Pub Date : 2025-07-01 Epub Date: 2025-05-16 DOI:10.1007/s13555-025-01425-y
Julien Seneschal, Lgnasi Figueras Nart, Silvia Sabatino, Manny Papadimitropoulos, Srishti Dabral, Anastasia Lampropoulou
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引用次数: 0

Abstract

Introduction: Baricitinib is an oral selective Janus kinase 1/2 inhibitor approved for the treatment of the immune-mediated inflammatory skin diseases atopic dermatitis (AD) and alopecia areata (AA). We report the findings of a systematic literature review of real-world outcomes with baricitinib in patients with AD or AA.

Methods: Databases, conference proceedings, and other sources were searched for publications covering July to November 2023 that provided real-world evidence in baricitinib-treated patients; extracted study variables included study population characteristics, interventions, and outcomes.

Results: In total, 76 publications meeting inclusion criteria were identified, most of which were single-centre studies; 1134 unique patients with AD and 598 unique patients with AA were included. Studies in AD mostly focused on effectiveness outcomes, followed by treatment patterns, patient-reported outcomes, and safety. Most AA publications focused on effectiveness outcomes, followed by safety then treatment patterns.

Conclusion: Overall, baricitinib consistently improved the signs and symptoms of AD in patients receiving baricitinib in real-world settings, was effective for the treatment of AA in both adult and paediatric patients and was associated with improvements in patient-reported outcomes. The most common reasons for baricitinib discontinuation in AD were ineffectiveness and adverse events, although discontinuation rates due to adverse events were low. Patients initiating baricitinib for AD had often been treated previously with a biologic and were frequently receiving immunosuppressive and topical treatments before treatment initiation. Treatment discontinuation and prior treatment data were limited for studies in AA, but several studies reported concomitant minoxidil use in patients with AA treated with baricitinib. No new safety signals for baricitinib were observed in patients with AD or AA, and no serious adverse events were reported. In conclusion, real-world data on baricitinib in the treatment of AD and AA support the effectiveness and tolerability reported in clinical trials.

巴西替尼治疗特应性皮炎和斑秃的真实证据:系统文献综述2020-2023。
Baricitinib是一种口服选择性Janus激酶1/2抑制剂,被批准用于治疗免疫介导的炎症性皮肤病特应性皮炎(AD)和斑秃(AA)。我们报告了对baricitinib治疗AD或AA患者的实际结果的系统文献综述的结果。方法:检索数据库、会议记录和其他来源,检索涵盖2023年7月至11月的出版物,这些出版物提供了baricitinib治疗患者的真实证据;提取的研究变量包括研究人群特征、干预措施和结果。结果:共纳入76篇符合纳入标准的文献,其中大部分为单中心研究;纳入1134例AD患者和598例AA患者。阿尔茨海默病的研究主要集中在有效性结果上,其次是治疗模式、患者报告的结果和安全性。大多数AA出版物关注的是有效性结果,其次是安全性,然后是治疗模式。结论:总体而言,baricitinib持续改善现实环境中接受baricitinib治疗的AD患者的体征和症状,对成人和儿科患者的AA治疗有效,并与患者报告结果的改善相关。baricitinib停药的最常见原因是无效和不良事件,尽管由于不良事件引起的停药率很低。开始使用巴西替尼治疗AD的患者以前经常用生物制剂治疗,并且在治疗开始前经常接受免疫抑制和局部治疗。在AA的研究中,停药和既往治疗的数据有限,但有几项研究报道了在接受巴西替尼治疗的AA患者中同时使用米诺地尔。baricitinib在AD或AA患者中未观察到新的安全性信号,也没有严重不良事件的报道。总之,baricitinib治疗AD和AA的实际数据支持临床试验报告的有效性和耐受性。
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来源期刊
Dermatology and Therapy
Dermatology and Therapy Medicine-Dermatology
CiteScore
6.00
自引率
8.80%
发文量
187
审稿时长
6 weeks
期刊介绍: Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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