Post-COVID-19 psychological condition in systemic lupus erythematosus patients: a prospective observational study.

IF 3.4 4区医学 Q2 RHEUMATOLOGY

Clinical and experimental rheumatology Pub Date : 2025-05-08 DOI:10.55563/clinexprheumatol/2uqnsn

Jingyi Wu, Lijuan Zhang, Zhuochao Zhou, Yaping Wu, Yue Sun, Fan Wang, Jialin Teng, Honglei Liu, Xiaobing Cheng, Yutong Su, Hui Shi, Qiongyi Hu, Jianfen Meng, Huihui Chi, Jinchao Jia, Tingting Liu, Mengyan Wang, Jian Li, Huiping Zhong, Chengde Yang, Junna Ye

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引用次数: 0

Abstract

Objectives: To assess the post-COVID-19 psychological condition of systemic lupus erythematosus (SLE) patients and the internal relationship between psychiatric symptoms.

Methods: A total of 619 SLE patients were included in this observational study, with 493 diagnosed with COVID-19 and 126 remaining uninfected. Visual analogue scale (VAS), Multi-dimensional Fatigue Inventory (MFI), Patient Health Questionnaire-9 (PHQ-9), and Pittsburgh Sleep Quality Index (PSQI) were utilised to assess pain, exhaustion, depression, and sleep quality, respectively. Network analysis found the core symptoms and bridge symptoms. Logistic regression was utilised to assess the impact of COVID-19 symptoms on later psychiatric symptoms.

Results: COVID-19 infected SLE patients had higher levels of pain, 'General Fatigue' (GF), PHQ-9, and PSQI ratings compared to others (p=0.006, 0.027, 0.003, and 0.049, respectively). The infected SLE patients' network of depression, fatigue, and sleep issues identified GF and 'Feeling down, hopeless' (PHQ2) as core symptoms with the greatest expected influence of 1.20. The symptoms 'Trouble sleeping' (PHQ3), GF and 'Daytime dysfunction' (DD) were bridge symptoms with greatest bridge expected influence of 0.72, 0.56 and 0.53, respectively. COVID-19 symptoms such as shortness of breath, weakness, and joint discomfort were linked to post-COVID-19 psychological condition.

Conclusions: Our study demonstrated a worse long-term mental status in COVID-19 infected SLE patients. Early screening and specific therapies might help prevent mental issues in SLE patients.

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系统性红斑狼疮患者新冠肺炎后的心理状况：一项前瞻性观察研究

目的：探讨新型冠状病毒肺炎（covid -19）后系统性红斑狼疮（SLE）患者的心理状况及其与精神症状的内在关系。方法：本观察性研究共纳入619例SLE患者，其中493例诊断为COVID-19, 126例未感染。采用视觉模拟量表（VAS）、多维疲劳量表（MFI）、患者健康问卷-9 （PHQ-9）和匹兹堡睡眠质量指数（PSQI）分别评估疼痛、疲惫、抑郁和睡眠质量。网络分析发现了核心症状和桥梁症状。采用Logistic回归评估COVID-19症状对后期精神症状的影响。结果：与其他患者相比，COVID-19感染的SLE患者具有更高水平的疼痛、“全身疲劳”（GF）、PHQ-9和PSQI评分（p分别=0.006、0.027、0.003和0.049）。感染SLE患者的抑郁、疲劳和睡眠问题网络将GF和“情绪低落、绝望”（PHQ2）确定为核心症状，预期影响最大（1.20）。“睡眠困难”（PHQ3）、“GF”和“白天功能障碍”（DD）是桥状症状，桥状预期影响最大，分别为0.72、0.56和0.53。COVID-19症状，如呼吸短促、虚弱和关节不适，与COVID-19后的心理状况有关。结论：我们的研究表明，COVID-19感染的SLE患者的长期精神状态更差。早期筛查和特异性治疗可能有助于预防SLE患者的精神问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and experimental rheumatology 医学-风湿病学

CiteScore

6.10

自引率

18.90%

发文量

377

审稿时长

3-6 weeks

期刊介绍： Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.