Low-level laser therapy in knee osteoarthritis: a narrative review.

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Xinyu Zhao, Xinyu Lou, Bing Wu, Haocheng Du, Lin Li, Qiusheng Zheng, Xin Guo, Weibo Xiao, Song Xue, Xintao Zhang
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Abstract

Knee osteoarthritis (KOA) is a degenerative joint disease that affects the entire knee joint, commonly seen in the elderly, and has shown an increasing trend toward younger populations in recent years. Its main symptoms include pain, swelling, stiffness, and limited mobility; besides, severe cases can lead to disability and complete loss of function.KOA can also lead to psychological issues such as depression and anxiety, posing substantial burdens on patients, families, and society. The current treatment options include physical therapy, medications, and other conservative methods, or surgical treatment. Notably, low-level laser therapy (LLLT) is a non-invasive and safe physical treatment that has been proven to be effective for various conditions affecting the musculoskeletal, nervous, and dermatological systems. Its non-invasive nature avoids the trauma and pain associated with surgery, and it avoids potential side effects of medication. Due to its convenience, safety, and effectiveness, LLLT has been widely recognised as a strategy for treating KOA. This review comprehensively examines the mechanisms of LLLT, including its capacity to modulate synovial macrophage polarisation and regulate the expression of inflammatory factors. It also provides an in-depth analysis of the clinical efficacy of LLLT as a standalone treatment or in conjunction with other therapeutic modalities for KOA patients, drawing on evidence from cellular, animal, and patient studies over recent decades. The aim is to offer robust theoretical support for the treatment of KOA.

低水平激光治疗膝骨关节炎:一个叙述性的回顾。
膝关节骨性关节炎(KOA)是一种影响整个膝关节的退行性关节疾病,常见于老年人,近年来在年轻人中呈增加趋势。其主要症状包括疼痛、肿胀、僵硬和活动受限;此外,严重者可导致残疾和完全丧失功能。KOA还可能导致抑郁和焦虑等心理问题,给患者、家庭和社会带来沉重负担。目前的治疗方案包括物理治疗、药物治疗和其他保守方法,或手术治疗。值得注意的是,低水平激光治疗(LLLT)是一种非侵入性和安全的物理治疗,已被证明对影响肌肉骨骼、神经和皮肤系统的各种疾病有效。它的非侵入性避免了与手术相关的创伤和疼痛,也避免了药物的潜在副作用。由于其便利性、安全性和有效性,LLLT已被广泛认为是治疗KOA的一种策略。这篇综述全面探讨了LLLT的机制,包括其调节滑膜巨噬细胞极化和调节炎症因子表达的能力。它还根据近几十年来细胞、动物和患者研究的证据,深入分析了LLLT作为单独治疗或与其他治疗方式联合治疗KOA患者的临床疗效。目的是为KOA的治疗提供有力的理论支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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