Association of serum myeloperoxidase with metabolic syndrome and adverse lipid profiles in scleroderma patients.

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Iván Ferraz-Amaro, Zena Ibrahim-Achi, Antonia de Vera-González, Mónica Renuncio-García, Esther F Vicente-Rabaneda, J Gonzalo Ocejo-Vinjals, Santos Castañeda, Miguel Ángel González-Gay
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引用次数: 0

Abstract

Objectives: Plasma myeloperoxidase (MPO) levels have been associated with cardiovascular disease in the general population. However, their relationship to cardiovascular manifestations in systemic sclerosis (SSc) remains unexplored. This study aims to investigate the association between circulating MPO and SSc disease characteristics, incorporating a comprehensive assessment of lipid profiles, carotid atherosclerosis, and metabolic syndrome.

Methods: This cross-sectional study encompassed 81 individuals with confirmed systemic sclerosis (SSc). All SSc patients underwent a complete clinical evaluation. Serum MPO levels and lipid profiles were assessed. To elucidate potential associations between MPO and both SSc-specific manifestations and cardiometabolic parameters, we employed multivariable linear regression analyses.

Results: Disease characteristics, including SSc subtype (diffuse or limited), Rodnan skin score, and the presence of visceral involvement (e.g., pulmonary, or other organ involvement) and autoantibody profiles, showed no correlation with MPO levels. However, significant and positive associations were observed, after multivariable adjustment, between MPO values and the presence of metabolic syndrome, LDL: HDL cholesterol ratio, non-HDL cholesterol, apolipoprotein B levels, apolipoprotein B:A1 ratio, and the atherogenic index.

Conclusions: Circulating MPO levels do not correlate with specific SSc disease manifestations. However, higher MPO values are associated with the presence of metabolic syndrome and an unfavorable lipid profile in patients with this condition.

血清髓过氧化物酶与硬皮病患者代谢综合征和不良脂质谱的关系。
目的:在普通人群中,血浆髓过氧化物酶(MPO)水平与心血管疾病相关。然而,它们与系统性硬化症(SSc)心血管表现的关系仍未被探索。本研究旨在探讨循环MPO与SSc疾病特征之间的关系,包括脂质谱、颈动脉粥样硬化和代谢综合征的综合评估。方法:本横断面研究纳入了81例系统性硬化症(SSc)患者。所有SSc患者都进行了完整的临床评估。评估血清MPO水平和血脂。为了阐明MPO与ssc特异性表现和心脏代谢参数之间的潜在关联,我们采用了多变量线性回归分析。结果:疾病特征,包括SSc亚型(弥漫性或局限性)、Rodnan皮肤评分、内脏受累(如肺或其他器官受累)和自身抗体谱,显示与MPO水平无关。然而,在多变量调整后,MPO值与代谢综合征、LDL: HDL胆固醇比、非HDL胆固醇、载脂蛋白B水平、载脂蛋白B:A1比和动脉粥样硬化指数之间存在显著正相关。结论:循环MPO水平与SSc疾病的特异性表现无关。然而,较高的MPO值与代谢综合征的存在和不利的脂质谱有关。
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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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