ADAMTS13 and insulin resistance in systemic sclerosis patients.

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Iván Ferraz-Amaro, Zena Ibrahim-Achi, Antonia de Vera-González, Mónica Renuncio-García, Esther F Vicente-Rabaneda, J Gonzalo Ocejo-Vinyals, Santos Castañeda, Miguel Ángel González-Gay
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引用次数: 0

Abstract

Objectivers: To investigate the complex interplay between autoimmune disorders, metabolic dysfunction, and vascular health, we assessed the relationship between ADAMTS13, systemic sclerosis-scleroderma (SSc), and insulin resistance.

Methods: A cross-sectional study was conducted involving 81 individuals diagnosed with SSc and 76 healthy age- and sex-matched controls. Comprehensive clinical and laboratory characterisations were performed for both groups. Serum levels of ADAMTS13, standard lipid profiles, and indices of insulin resistance were assessed in all participants. To determine whether ADAMTS13 serum levels differed significantly between SSc patients and healthy controls, as well as to examine the relationship between ADAMTS13 values, disease characteristics, and cardiometabolic features, multivariable linear regression analyses were performed.

Results: Serum ADAMTS13 levels were significantly decreased in patients with SSc compared to healthy controls after multivariable analysis. A significant negative correlation was observed between C-reactive protein levels and circulating ADAMTS13 levels. However, disease characteristics, including pulmonary, articular, and cutaneous manifestations, did not show significant associations with ADAMTS13 values. Regarding cardiometabolic features, ADAMTS13 levels demonstrated a significant positive association with indices of insulin resistance, a relationship not observed in the control group.

Conclusions: ADAMTS13 serum levels are decreased in patients with SSc. Additionally, a positive correlation exists between ADAMTS13 levels and insulin resistance in SSc.

系统性硬化症患者ADAMTS13与胰岛素抵抗的关系
目的:为了研究自身免疫性疾病、代谢功能障碍和血管健康之间的复杂相互作用,我们评估了ADAMTS13、系统性硬化症-硬皮病(SSc)和胰岛素抵抗之间的关系。方法:对81名SSc患者和76名年龄和性别匹配的健康对照组进行了横断面研究。两组患者均进行了全面的临床和实验室特征分析。评估所有参与者的血清ADAMTS13水平、标准脂质谱和胰岛素抵抗指标。为了确定SSc患者与健康对照者的ADAMTS13血清水平是否存在显著差异,并检验ADAMTS13值与疾病特征和心脏代谢特征之间的关系,我们进行了多变量线性回归分析。结果:经多变量分析,SSc患者血清ADAMTS13水平明显低于健康对照组。c反应蛋白水平与循环ADAMTS13水平呈显著负相关。然而,疾病特征,包括肺、关节和皮肤表现,没有显示出与ADAMTS13值的显著关联。在心脏代谢特征方面,ADAMTS13水平与胰岛素抵抗指数呈显著正相关,而在对照组中未观察到这种关系。结论:SSc患者血清ADAMTS13水平降低。此外,在SSc中ADAMTS13水平与胰岛素抵抗之间存在正相关。
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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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