Keloids revisited: Current concepts in treatment and differential diagnosis

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2025-05-14 DOI:10.1016/j.canlet.2025.217802

Yanhui Liu , Xiao Chen , Katharina S. Fischer , Siqi Fu , Li Yuan , Xing Hu

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引用次数: 0

Abstract

Keloid is a special type of scar considered prototypic of skin fibrosis. Unlike hypertrophic scars, keloids exceed the margins of the original wound, and exist over time without a quiescent or regressive phase. Although keloids do not metastasize, they exhibit tumor-like characteristics, and share many similarities. Large epidemiological study demonstrates that patients with keloids have a 1.49-fold higher risk for cancers. Keloids can lead to severe functional impairments and diminish quality of life which increases hidden costs for patients and medical systems. The main goals of treatments are to improve scar appearance, symptoms and patient's quality of life (QoL). However, the microenvironment, pathogenesis, formation and development of the keloid are complex, the efficacy of multiple treatments were limited. Therefore, this up-to-date review aimed to target the current concepts in keloid treatment and differential diagnosis. The goal is to provide a reference for doctors and researchers to improve the accuracy of diagnosis and facilitate the selection of personalized treatment methods for patients with keloids.

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瘢痕疙瘩重述：当前治疗和鉴别诊断的概念。

瘢痕疙瘩是一种特殊类型的疤痕，被认为是皮肤纤维化的原型。与肥厚性疤痕不同，瘢痕疙瘩超出原始伤口的边缘，并随着时间的推移而存在，没有静止或退行期。虽然瘢痕疙瘩不会转移，但它们表现出肿瘤样特征，并有许多相似之处。大型流行病学研究表明，瘢痕疙瘩患者患癌症的风险高出1.49倍。瘢痕疙瘩可导致严重的功能损伤，降低生活质量，从而增加患者和医疗系统的隐性成本。治疗的主要目标是改善疤痕外观，症状和患者的生活质量（QoL）。然而，瘢痕疙瘩的微环境、发病机制、形成发展复杂，多种治疗方法疗效有限。因此，这篇最新的综述旨在针对目前瘢痕疙瘩治疗和鉴别诊断的概念。目的是为医生和研究人员提供参考，以提高瘢痕疙瘩患者的诊断准确性，方便选择个性化的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.