Mechanisms of tumor-associated macrophages promoting tumor immune escape.

IF 3.3 3区 医学 Q2 ONCOLOGY
Shengfen Li, Mengxia Zhang, Yuan Gao, Can Zhao, Shuxian Liao, Xuhong Zhao, Qian Ning, Shengsong Tang
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引用次数: 0

Abstract

The phenomenon of tumor immune escape involves multiple mechanisms that enable tumor cells to evade recognition and assault by the host's immune system, facilitating their survival and growth within the organism. Furthermore, tumor immune escape represents a critical mechanism in tumor progression and significantly contributes to the unsuccessful outcomes of immunotherapy. Tumor-associated macrophages (TAMs) are recruited into the tumor microenvironment (TME), serving a pivotal role in modulating tumor immune escape. An increasing body of research has demonstrated that TAMs are linked to unfavorable cancer prognosis and drug resistance. They suppress immune cell activity, hinder antigen presentation, and inhibit T cell activation, thereby helping tumor cells evade immune attacks. Consequently, elucidating the mechanisms by which TAMs promote tumor immune escape is crucial for developing novel immunotherapeutic strategies and improving the efficacy of cancer immunotherapy. In terms of clinical relevance, studies on TAMs have revealed their significant roles in various types of cancer. In recent years, transformational therapies such as CSF-1R inhibitors and CD40 agonists targeting TAMs have entered clinical trials and are expected to reverse immunosuppression and enhance immunotherapy response. These studies provide new directions for improving the effectiveness of existing immunotherapies and overcoming drug resistance.

肿瘤相关巨噬细胞促进肿瘤免疫逃逸的机制。
肿瘤免疫逃逸现象涉及多种机制,使肿瘤细胞能够逃避宿主免疫系统的识别和攻击,促进其在机体内的生存和生长。此外,肿瘤免疫逃逸是肿瘤进展的关键机制,也是导致免疫治疗失败的重要原因。肿瘤相关巨噬细胞(TAMs)被招募到肿瘤微环境(TME)中,在调节肿瘤免疫逃逸中起着关键作用。越来越多的研究表明,tam与不良的癌症预后和耐药性有关。它们抑制免疫细胞活性,阻碍抗原呈递,抑制T细胞活化,从而帮助肿瘤细胞逃避免疫攻击。因此,阐明tam促进肿瘤免疫逃逸的机制对于开发新的免疫治疗策略和提高肿瘤免疫治疗效果至关重要。在临床相关性方面,对tam的研究已经揭示了它们在各种类型的癌症中的重要作用。近年来,针对tam的CSF-1R抑制剂和CD40激动剂等转化疗法已进入临床试验,有望逆转免疫抑制并增强免疫治疗反应。这些研究为提高现有免疫疗法的有效性和克服耐药性提供了新的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Carcinogenesis
Carcinogenesis 医学-肿瘤学
CiteScore
9.20
自引率
2.10%
发文量
95
审稿时长
1 months
期刊介绍: Carcinogenesis: Integrative Cancer Research is a multi-disciplinary journal that brings together all the varied aspects of research that will ultimately lead to the prevention of cancer in man. The journal publishes papers that warrant prompt publication in the areas of Biology, Genetics and Epigenetics (including the processes of promotion, progression, signal transduction, apoptosis, genomic instability, growth factors, cell and molecular biology, mutation, DNA repair, genetics, etc.), Cancer Biomarkers and Molecular Epidemiology (including genetic predisposition to cancer, and epidemiology), Inflammation, Microenvironment and Prevention (including molecular dosimetry, chemoprevention, nutrition and cancer, etc.), and Carcinogenesis (including oncogenes and tumor suppressor genes in carcinogenesis, therapy resistance of solid tumors, cancer mouse models, apoptosis and senescence, novel therapeutic targets and cancer drugs).
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