Heart Conditioning as a Healthy Strategy in Management of Cardiac Enlargement.

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research Pub Date : 2025-06-01 Epub Date: 2025-03-28 DOI:10.14740/cr2047

David Wing-Ching Lee, William Wing-Ho Lee, Andrew Ying-Siu Lee

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Abstract

Background: Remote ischemic conditioning (RIC) is widely recognized for its cardioprotective effects in the context of ischemic heart disease. Lately, it has been shown that heart conditioning can be utilized as a healthy strategy in the reversion of disease and aging. In this regard, we examine the impact of RIC on patients with cardiac enlargement.

Methods: Forty-four patients with cardiac enlargement were prospectively enrolled and randomly assigned into RIC group (n = 22) and control group (n = 22). RIC protocol is 3-min inflation/deflation of the blood pressure cuff applied in the upper arm to create transient arm ischemia. RIC treatment was performed once a day for 1 year. Left atrial and ventricular dimensions and left ventricular ejection fraction (LVEF) were all assessed in two groups.

Results: RIC was well-tolerated. After 1 year treatment, left atrial and ventricular dimensions were significantly decreased in the RIC group. Moreover, LVEF showed a significant increase, from 46.24% to 56.45% (P < 0.0001).

Conclusion: The research indicates that a year-long healthy regimen of RIC treatment may effectively reverse cardiac enlargement, thereby endorsing the broader implementation of RIC in the daily routines of these patients.

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心脏调节是处理心脏肿大的健康策略。

背景：远程缺血调节（RIC）因其在缺血性心脏病中的心脏保护作用而被广泛认可。最近，研究表明，心脏调节可以作为一种健康的策略，用于逆转疾病和衰老。在这方面，我们研究了RIC对心脏增大患者的影响。方法：前瞻性纳入44例心脏增大患者，随机分为RIC组（n = 22）和对照组（n = 22）。RIC方案是在上臂施加3分钟的血压袖带充气/放气，以造成短暂的手臂缺血。RIC治疗每天1次，持续1年。两组患者均观察左房、左室尺寸及左室射血分数（LVEF）。结果：RIC耐受性良好。治疗1年后，RIC组左心房和心室尺寸明显减小。LVEF从46.24%显著增加到56.45% （P < 0.0001）。结论：本研究表明，一年的RIC健康治疗方案可以有效逆转心脏增大，从而支持在这些患者的日常生活中更广泛地实施RIC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.