Managing bipolar affective disorder in chronic kidney disease when lithium is no longer an option.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Kate Corrigan, Darragh Larkin, Margaret Gallagher, Allys Guerandel
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引用次数: 0

Abstract

The therapeutic benefits of lithium use in bipolar affective disorder (BPAD) are well established; however, it can cause adverse side effects including chronic kidney disease and progression to end-stage renal disease (ESRD). We describe the cases of two patients with BPAD stable on lithium for many years. In both cases, kidney function declined towards ESRD, prompting cessation of lithium therapy and precipitating a period of mental instability. Concurrent lithium and haemodialysis treatment was successfully trialled in case 2. There is a dearth of guidance on managing those on lithium therapy with kidney disease progressing towards ESRD. We describe the management and outcomes of two such patients attending a community mental health team.

管理双相情感障碍在慢性肾脏疾病时,锂不再是一种选择。
锂离子治疗双相情感障碍(BPAD)的益处已得到充分证实;然而,它会引起不良的副作用,包括慢性肾脏疾病和进展到终末期肾脏疾病(ESRD)。我们描述了两例患者BPAD稳定锂多年。在这两种情况下,肾功能下降到ESRD,促使停止锂治疗和沉淀一段时间的精神不稳定。同时锂离子和血液透析治疗在病例2中试验成功。目前缺乏锂治疗肾病进展为终末期肾病患者的管理指南。我们描述了两个这样的病人参加社区精神卫生小组的管理和结果。
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来源期刊
BMJ Case Reports
BMJ Case Reports Medicine-Medicine (all)
CiteScore
1.40
自引率
0.00%
发文量
1588
期刊介绍: BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.
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