Effects of the carcinogen TCDD on δ-catenin stability and tumorigenic potential in prostate cancer cells.

IF 3.6 3区医学 Q2 ONCOLOGY

American journal of cancer research Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI:10.62347/WRBD9281

Yue Niu, Hyoung Jae Lee, Zhiwei Chen, Hangun Kim, Kwonseop Kim

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引用次数: 0

Abstract

δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins and is known to be upregulated in prostate cancer, promoting tumorigenesis. Unfortunately, the molecular mechanism underlying this effect remains unclear. The carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been linked to an increased risk of prostate cancer. In this study, we explored the effect of TCDD on δ-catenin in prostate cancer cells. TCDD increased the protein levels of δ-catenin in a dose-dependent manner by enhancing its stability. Moreover, TCDD led to an increase in β-catenin expression but a decrease in E-cadherin levels. Further experiments revealed that TCDD stabilized the expression of δ-catenin by inhibiting its ubiquitination-mediated degradation. Finally, TCDD enhanced the motility and migration ability of prostate cancer cells through δ-catenin. These findings suggest that TCDD plays a role in stabilizing δ-catenin in prostate cancer cells, offering a new perspective on preventing δ-catenin degradation and potentially increasing the predictive value of δ-catenin for prostate cancer.

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致癌物TCDD对前列腺癌细胞δ-连环蛋白稳定性和致瘤潜能的影响。

δ-Catenin是犰狳蛋白p120-catenin亚家族的成员，已知在前列腺癌中表达上调，促进肿瘤发生。不幸的是，这种作用的分子机制尚不清楚。致癌物质2,3,7,8-四氯二苯并-对二恶英（TCDD）与前列腺癌风险增加有关。本研究探讨了TCDD对前列腺癌细胞δ-catenin的影响。TCDD通过增强δ-catenin的稳定性，呈剂量依赖性地增加δ-catenin的蛋白水平。此外，TCDD导致β-catenin表达增加，而E-cadherin水平降低。进一步实验表明，TCDD通过抑制δ-catenin泛素化介导的降解来稳定δ-catenin的表达。最后，TCDD通过δ-catenin增强前列腺癌细胞的运动性和迁移能力。这些发现提示TCDD在稳定前列腺癌细胞δ-catenin中发挥作用，为防止δ-catenin降解提供了新的视角，并有可能提高δ-catenin对前列腺癌的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of cancer research ONCOLOGY-

自引率

3.80%

发文量

263

期刊介绍： The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.