Palladium analogues as complementary of Cis-platin- a mini review

IF 2.6 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Polyhedron Pub Date : 2025-05-16 DOI:10.1016/j.poly.2025.117585

Arup Mandal

引用次数: 0

Abstract

Cis-platin was the first discovered anticancer drug based on the transition metal complex. It showed its anticancer activities on various types of cancers such as head and neck, testicular, small-cell lung and non-small-cell lung, bladder, cervical and ovarian cancers. But due to some adverse effects, scientists developed some platinum analogues as second and third generation drugs for cancer treatment. Among them, some passed clinical trials and some failed. Then non platinum complexes were also introduced with effective anticancer properties. Lot of research has been done on Iron, Ruthenium, Rhodium analogues. In this review, immense bio-activity of Palladium Complexes has been discussed and tried to demonstrate that Palladium complexes and its derivatives may also function as alternatives of Cis-platin.

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钯类似物作为顺铂的补充物——综述

顺式铂是第一个发现的基于过渡金属配合物的抗癌药物。对头颈癌、睾丸癌、小细胞肺癌和非小细胞肺癌、膀胱癌、宫颈癌和卵巢癌等多种癌症均有抗癌作用。但由于一些副作用，科学家们开发了一些铂类似物作为治疗癌症的第二代和第三代药物。其中有通过临床试验的，也有失败的。然后介绍了具有有效抗癌性能的非铂配合物。人们对铁，钌，铑的类似物做了很多研究。本文讨论了钯配合物的巨大生物活性，并试图证明钯配合物及其衍生物也可以作为顺铂的替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.