DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1

IF 4.5 3区医学 Q1 MICROBIOLOGY

International Journal of Medical Microbiology Pub Date : 2025-05-07 DOI:10.1016/j.ijmm.2025.151654

Peijun Han , Wei Ye , Hongwei Ma , Yangchao Dong , Xin Lv , He Liu , Linfeng Cheng , Liang Zhang , Sumin Li , Yingfeng Lei , Fanglin Zhang

引用次数: 0

Abstract

Dengue virus (DENV) is one of the major arboviruses that pose a serious threat to global human health. However, there is currently no specific antiviral drug available for the treatment of DENV infection. DDX17, a member of the DExD/H-box helicase family, has been implicated in the replication processes of various viruses. Our research group discovered that during the early stages of dengue virus replication, DDX17 promotes viral replication and suppresses the activity of the IFN promoter. Furthermore, DDX17 binds to viral dsRNA and interacts with G3BP1, a component of stress granules (SGs), to inhibit SG formation, thereby enhancing viral replication. By elucidating the role of DDX17 in the early stages of dengue virus replication, our findings provide valuable insights into host-pathogen interactions during DENV infection, offering potential therapeutic perspectives.

查看原文本刊更多论文

DDX17通过与病毒dsRNA和G3BP1相互作用促进DENV-2复制

登革热病毒（DENV）是严重威胁全球人类健康的主要虫媒病毒之一。然而，目前还没有特定的抗病毒药物可用于治疗DENV感染。DDX17是DExD/H-box解旋酶家族的一员，参与多种病毒的复制过程。我们的研究小组发现，在登革热病毒复制的早期阶段，DDX17促进病毒复制并抑制IFN启动子的活性。此外，DDX17与病毒dsRNA结合，并与应激颗粒（SGs）的组分G3BP1相互作用，抑制应激颗粒的形成，从而增强病毒复制。通过阐明DDX17在登革热病毒复制早期阶段的作用，我们的研究结果为DENV感染过程中宿主-病原体相互作用提供了有价值的见解，并提供了潜在的治疗前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Medical Microbiology 医学-病毒学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

45 days

期刊介绍： Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.