Inhibitory effects of γ-linolenic acid on contractile responses in pig coronary arteries: Possible involvement of prostanoid TP receptor inhibition

IF 2.9 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2025-05-12 DOI:10.1016/j.jphs.2025.05.009

Keisuke Obara , Kento Yoshioka , Mikoto Ozawa, Haruki Kimura, Mayu Kiguchi, Yuri Nakao, Hinako Miyaji, Toma Yamashita, Noboru Saitoh, Yutaka Nakagome, Sakika Ichihara, Yoshio Tanaka

引用次数: 0

Abstract

We examined whether γ-linolenic acid (GLA), an n−6 polyunsaturated fatty acid (PUFA) and a structural isomer of α-linolenic acid (an n−3 PUFA), inhibited contractions of isolated pig coronary arteries. GLA potently inhibited the contractions elicited by U46619/prostaglandin F_2α, while showing marginal effects against other contractions. Schild plot analysis of GLA versus U46619 showed a competitive antagonistic effect. GLA also inhibited the intracellular Ca²⁺ concentration increases caused by prostanoid TP but not by FP receptor stimulation. These results suggest that TP receptor antagonistic activity can be exhibited by non-n−3 PUFAs in coronary arteries.

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γ-亚麻酸对猪冠状动脉收缩反应的抑制作用：可能与前列腺素TP受体抑制有关

我们研究了γ-亚麻酸（GLA），一种n - 6多不饱和脂肪酸（PUFA）和α-亚麻酸（n - 3 PUFA）的结构异构体是否能抑制离体猪冠状动脉的收缩。GLA能有效抑制U46619/前列腺素F2α引起的收缩，而对其他收缩作用微弱。GLA对U46619的Schild图分析显示出竞争性拮抗作用。GLA还抑制前列腺素TP引起的细胞内Ca2+浓度升高，而不抑制FP受体的刺激。这些结果表明，冠状动脉中的非n- 3 PUFAs可以表现出TP受体的拮抗活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.