Head-and-neck cooling has a greater effect on motor performance in unpredictable tasks than in constant and predictable ones for men with multiple sclerosis: A randomized crossover study

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2025-05-17 DOI:10.1016/j.msard.2025.106525

Gintare Dauksaite , Nerijus Eimantas , Rima Solianik , Laura Daniuseviciute-Brazaite , Lina Malciene , Marius Brazaitis

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引用次数: 0

Abstract

Objective

To determine the effects of different motor tasks (constant vs. predictable vs. unpredictable), as well as head-and-neck cooling, on central and peripheral fatigability, physiological-thermal stress, and motor system function in men with multiple sclerosis (MS).

Methods

Eighteen male MS volunteers (aged 34.9 ± 8.1 years) were allocated to one of two groups: the head-and-neck cooling group (COLD) or the control group (CON), which received no thermal intervention. Each group participated in three exercise trials, each structured with variations in simulated contraction intensity (constant, predictable, and unpredictable), with at least one week between trials. The trials involved 100 intermittent isometric contraction tasks, targeting knee extensions at a 60° flexion angle. Fatiguing motor tasks involved 5-second contractions followed by 20-second rest periods. Key variables were assessed before, during, and after a 1-hour recovery period.

Results

Head-and-neck cooling reduced central fatigability, improved perceived exertion, and elevated electromyography amplitude across all motor task strategies (p < 0.05). When combined with head-and-neck cooling, the unpredictable motor task induced greater modulation of central and peripheral motor performance variables than the constant and predictable ones. Additionally, predictable and unpredictable motor tasks caused greater peripheral fatigability than constant tasks in both the COLD and CON groups (p < 0.05).

Conclusion

An unpredictable motor task combined with head-and-neck cooling enhances central activation of exercising muscles, leading to lower central fatigability and improved perceived exertion, while also inducing greater peripheral fatigability, as evidenced by reduced force generation and greater motor errors compared to constant and predictable ones in men with MS.

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一项随机交叉研究表明，对于多发性硬化症患者来说，头颈冷却在不可预测的任务中对运动表现的影响比在恒定和可预测的任务中更大

目的探讨不同运动任务（恒定、可预测、不可预测）以及头颈部冷却对多发性硬化症（MS）患者中枢和外周疲劳、生理性热应激和运动系统功能的影响。方法将18名男性MS志愿者（34.9±8.1岁）分为头颈降温组（COLD）和对照组（CON），对照组不进行热干预。每组都参加了三个运动试验，每个试验都有模拟收缩强度的变化（恒定的、可预测的和不可预测的），试验之间至少间隔一周。试验包括100个间歇等距收缩任务，目标是膝关节以60°屈曲角度伸展。疲劳运动任务包括5秒的收缩，然后是20秒的休息时间。在恢复期前、恢复期中和恢复期后分别对关键变量进行评估。结果头颈冷却降低了中枢疲劳，改善了感知劳累，并提高了所有运动任务策略的肌电振幅(p <；0.05)。当与头颈冷却相结合时，与恒定和可预测的运动任务相比，不可预测的运动任务诱导了更大的中枢和外围运动性能变量的调节。此外，在COLD组和CON组中，可预测和不可预测的运动任务比恒定任务引起更大的周围疲劳(p <；0.05)。结论：不可预测的运动任务与头颈冷却相结合，增强了运动肌肉的中枢激活，导致中枢性疲劳降低，改善了感知运动，同时也引起了更大的周围疲劳，与恒定和可预测的运动任务相比，MS患者的力产生减少，运动错误更大。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.