Cerium oxide luminescent sensors for hydrogen peroxide detection with fetal bovine serum – enhanced sensitivity and aggregation stability in biological environments

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Liquids Pub Date : 2025-05-15 DOI:10.1016/j.molliq.2025.127798

Yevhen Neuhodov , Vladyslav Seminko , Pavel Maksimchuk , Ganna Grygorova , Kateryna Hubenko , Nataliya Kavok , Galyna Dudetskaya , Yurii Kot , Svitlana Yefimova

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引用次数: 0

Abstract

The effect of fetal bovine serum (FBS) on the aggregation stability and hydrogen peroxide (HP) – sensing properties of CeO_2-x NPs in water solutions and biological media (DMEM, Hanks, and C199) is reported. The presence of FBS both improves the stability of CeO_2-x NPs in highly ionic biological media, and increases the luminescence intensity of CeO_2-x NPs due to additional Ce⁴⁺→Ce³⁺ reduction. FBS-stabilized CeO_2-x luminescent sensors demonstrate improved HP sensitivity being able to determine HP concentrations in the micromolar range with linear HP concentration dependences from tens of μM to hundreds of mM. The luminescence sensors are reversible due to Ce³⁺ ↔ Ce⁴⁺ regeneration ability in nanoceria and able for multi-use in both water solutions and biological liquids.

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用胎牛血清检测过氧化氢的氧化铈发光传感器——生物环境中增强的灵敏度和聚集稳定性

报道了胎牛血清（FBS）对CeO2-x NPs在水溶液和生物介质（DMEM、Hanks和C199）中的聚集稳定性和过氧化氢（HP）传感性能的影响。FBS的存在不仅提高了CeO2-x NPs在高离子生物介质中的稳定性，而且由于Ce4+→Ce3+的额外还原，提高了CeO2-x NPs的发光强度。fbs稳定的CeO2-x发光传感器显示出改进的高压灵敏度，能够测定微摩尔范围内的高压浓度，高压浓度线性依赖于几十μM到数百mM。由于Ce3+↔Ce4+在纳米微球中的再生能力，发光传感器是可逆的，并且能够在水溶液和生物液体中多用途。

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.