Dr. Linda R. Watkins: A pioneer who rewrote the science of pain and neuroimmune signaling

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-05-15 DOI:10.1016/j.bbi.2025.05.013

Mark R. Hutchinson , Erin D. Milligan , Peter M. Grace

引用次数: 0

Abstract

Dr. Linda R. Watkins, a Distinguished Professor at the University of Colorado Boulder, fundamentally altered the understanding of pain and neuroimmune signaling. As she concludes her tenure as Associate Editor of Brain, Behavior, and Immunity, this tribute reflects on her revolutionary discoveries. She pioneered the concept that glial cells actively participate in pain states, challenging neuron-centric dogma. Her work elucidated the roles of cytokines like IL-1β and IL-10, the chemokine fractalkine (CX3CL1), and the Toll-Like Receptor 4 (TLR4) in glial reactivity, sickness behavior, and unwanted opioid effects (tolerance, hyperalgesia). As a dedicated mentor and collaborator, particularly with Steve Maier, she fosters interdisciplinary research. Watkins champions translational science, co-founding Xalud Therapeutics to develop immune therapies like IL-10 gene therapy, leaving a profound legacy in neuroscience.

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琳达·r·沃特金斯博士：改写疼痛和神经免疫信号科学的先驱

科罗拉多大学博尔德分校的杰出教授琳达·r·沃特金斯博士从根本上改变了对疼痛和神经免疫信号的理解。在她作为《大脑、行为和免疫》杂志副主编的任期结束之际，这篇文章回顾了她的革命性发现。她开创了神经胶质细胞积极参与疼痛状态的概念，挑战了神经元中心的教条。她的工作阐明了细胞因子如IL-1β和IL-10、趋化因子fractalkine （CX3CL1）和toll样受体4 （TLR4）在胶质反应性、疾病行为和不必要的阿片效应（耐受性、痛觉过敏）中的作用。作为一个专门的导师和合作者，特别是与史蒂夫·迈尔，她促进跨学科研究。沃特金斯支持转化科学，与人共同创立了Xalud Therapeutics，开发IL-10基因疗法等免疫疗法，在神经科学领域留下了深刻的遗产。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.