Antibacterial activity of graphene oxide/ZnO/salicylic acid composite against gram-negative and gram-positive bacteria

IF 4.3 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Chemistry and Physics Pub Date : 2025-05-13 DOI:10.1016/j.matchemphys.2025.131020

Adi Darmawan, Alviyani Pratiwi, Muhibbudin Al Fahmi, Hasan Muhtar, Rachel Maulida Tsuraya, Yayuk Astuti

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引用次数: 0

Abstract

Bacterial infections pose a significant threat to human health, highlighting the need for materials with effective antibacterial properties. This study investigates the antibacterial potential of a composite material composed of graphene oxide (GO), zinc oxide (ZnO), and salicylic acid (SA). The GO/ZnO/SA composite was synthesized via a simple precipitation method and evaluated for its antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The primary objective of this study is to determine the optimal composition of GO, ZnO, and SA to achieve the highest antibacterial activity. The results indicate that the GO/ZnO/SA composite with a higher proportion of ZnO and SA exhibited significant antibacterial properties against both E. coli and S. aureus. Among the various composite compositions, the GO/ZnO-3/SA-3 composite (GO:ZnO:SA = 1:6.6:22.8) demonstrated the highest inhibition, achieving 88.1 % inhibition against E. coli and 79.2 % inhibition against S. aureus after 20 h of incubation. Notably, bacterial growth inhibition efficiency increased with higher concentrations of ZnO and SA. These findings underscore the potential of the GO/ZnO/SA composite as a promising antibacterial material effective against both Gram-negative and Gram-positive bacteria.

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氧化石墨烯/氧化锌/水杨酸复合材料对革兰氏阴性和革兰氏阳性细菌的抑菌活性

细菌感染对人类健康构成重大威胁，凸显了对具有有效抗菌性能的材料的需求。本研究探讨了由氧化石墨烯（GO）、氧化锌（ZnO）和水杨酸（SA）组成的复合材料的抗菌潜力。采用简单沉淀法合成了氧化石墨烯/氧化锌/SA复合材料，并对其对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）的抗菌活性进行了评价。本研究的主要目的是确定氧化石墨烯、氧化锌和SA的最佳组成，以达到最高的抗菌活性。结果表明，氧化锌和SA比例较高的氧化石墨烯/氧化锌/SA复合材料对大肠杆菌和金黄色葡萄球菌均具有显著的抗菌性能。其中，氧化石墨烯/ZnO-3/SA-3复合物（GO:ZnO:SA = 1:6.6:22.8）对大肠杆菌和金黄色葡萄球菌的抑制作用最高，培养20 h后分别达到88.1%和79.2%。值得注意的是，氧化锌和SA浓度越高，细菌生长抑制效率越高。这些发现强调了氧化石墨烯/氧化锌/SA复合材料作为一种有前途的抗菌材料的潜力，可以有效地对抗革兰氏阴性和革兰氏阳性细菌。

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来源期刊

Materials Chemistry and Physics 工程技术-材料科学：综合

CiteScore

8.70

自引率

4.30%

发文量

1515

审稿时长

69 days

期刊介绍： Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.