Cytokines and immune effector cell therapy

IF 2 4区医学 Q3 HEMATOLOGY

Best Practice & Research Clinical Haematology Pub Date : 2025-05-08 DOI:10.1016/j.beha.2025.101628

Alexandra Haugh, Matthew J. Frigault

引用次数: 0

Abstract

Cytokines play an integral role in both promoting the efficacy of immune effector cell (IEC) therapies and in the development of the unique spectrum of associated toxicities, including CRS, ICANS, and IEC-HS. We review the various cytokines that have been employed in the IEC manufacturing process as well as the role of endogenous cytokines in promoting successful expansion and activity following cell infusion. We discuss the role of recombinant exogenous cytokines in further promoting T cell activity, as well as next-generation IEC products engineered to express cytokines that signal in an autonomous fashion. Finally, we discuss working models of several IEC-associated toxicities, highlighting the crucial role of cytokines in driving these toxicities, as well as interventions with anti-cytokine therapies to overcome them.

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细胞因子和免疫效应细胞疗法

细胞因子在促进免疫效应细胞（IEC）治疗的疗效和形成独特的相关毒性谱（包括CRS、ICANS和IEC- hs）方面发挥着不可或缺的作用。我们回顾了在IEC制造过程中使用的各种细胞因子，以及内源性细胞因子在细胞输注后促进成功扩增和活性的作用。我们讨论了重组外源性细胞因子在进一步促进T细胞活性中的作用，以及下一代IEC产品，这些产品旨在表达以自主方式发出信号的细胞因子。最后，我们讨论了几种iec相关毒性的工作模型，强调了细胞因子在驱动这些毒性中的关键作用，以及抗细胞因子治疗的干预措施来克服它们。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research Clinical Haematology 医学-血液学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.