A novel strategy for drug recycling: Fabrication and characterization of paracetamol-derived self-assembled monolayer films on copper for enhanced corrosion protection

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Liquids Pub Date : 2025-05-10 DOI:10.1016/j.molliq.2025.127751

Selman Boylu , Ramazan Solmaz

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引用次数: 0

Abstract

Increasing disposal of unused or expired medication has been causing severe environmental problems and economic losses. Pharmaceutical recycling offers a realistic and potentially impactful means of resisting these challenges. This study introduces a novel approach to sustainability through the recycling of paracetamol (PC) for the first time to fabricate self-assembled monolayer (SAM) films on Cu substrates. SAMs were prepared in ethanol as the solvent with varying PC concentrations over 24 h at 298 K and were characterized using energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), atomic force microscopy (AFM), and Fourier transform infrared spectroscopy (FT-IR). Corrosion protection performance of PC-SAM films was evaluated in 3.5 % NaCl solution. The results indicated a strong dependence of film properties on PC concentration, with the 250 ppm PC formulation providing the highest corrosion protection efficiency of 94.4 %. The PC-SAM films were homogeneous, compact, and exhibited excellent adhesion on the Cu surface. To our knowledge, this novel strategy is the first reported use of a pharmaceutical waste compound to generate SAM films on metallic surfaces, introducing a dual-function approach combining pharmaceutical recycling with advanced material protection. The findings demonstrate a new route toward eco-friendly and cost-effective corrosion inhibitors, contributing to green chemistry and circular economy.

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一种新的药物回收策略：对乙酰氨基酚衍生的铜自组装单层膜的制备和表征，用于增强腐蚀保护

越来越多的未使用或过期药物的处理已经造成严重的环境问题和经济损失。药物回收为应对这些挑战提供了一种现实和潜在的有效手段。本研究首次介绍了一种利用扑热息痛（PC）在Cu衬底上制备自组装单层（SAM）薄膜的可持续性新方法。以乙醇为溶剂，以不同浓度的PC在298 K下加热24 h制备了SAMs，并使用能量色散x射线光谱（EDX）、扫描电子显微镜（SEM）、原子力显微镜（AFM）和傅里叶变换红外光谱（FT-IR）对其进行了表征。在3.5% NaCl溶液中对PC-SAM膜的防腐性能进行了评价。结果表明，薄膜性能与PC浓度有很强的相关性，其中250 ppm PC配方的防腐效率最高，为94.4%。PC-SAM薄膜均匀致密，在Cu表面表现出良好的附着力。据我们所知，这种新策略是首次报道使用药物废物化合物在金属表面产生SAM膜，引入了一种将药物回收与先进材料保护相结合的双重功能方法。这一发现为开发生态友好且具有成本效益的缓蚀剂开辟了一条新途径，为绿色化学和循环经济做出了贡献。

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.