Outcomes of Salvage Surgery for Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck Following Definitive Surgery and Radiation Therapy.

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

Annals of Otology Rhinology and Laryngology Pub Date : 2025-07-01 Epub Date: 2025-05-03 DOI:10.1177/00034894251335402

Nikhil Bellamkonda, Marcus M Monroe

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引用次数: 0

Abstract

Objective: To describe outcomes of patients with a history of cutaneous squamous cell carcinoma (cSCC) of the head and neck previously treated with definitive surgery and radiation therapy (RT), who undergo salvage surgery for disease recurrence. There is minimal data available on this cohort of patients.

Methods: This was a retrospective case series. Patients evaluated for advanced cSCC of the head and neck between 2003 and 2022 were reviewed. Those with a history of surgery and adjuvant RT undergoing salvage surgery for recurrence were included in the main cohort. Comparisons were made to patients undergoing primary/initial treatment, and to those undergoing salvage surgery for recurrence but without a history of adjuvant RT.

Results: Of the 579 patients reviewed, 49 met inclusion criteria for the main cohort. Average length of follow up was 22 months. A total of 19 patients (38.8%) experienced recurrence, all within 14 months of salvage surgery. Among patents staged BWH T2b or T3, there was a 50% recurrence rate. Average overall survival following surgery was 35.6 months (95% CI = 24.7-46.4).

Conclusion: Patients in this cohort have a high rate of recurrence and an overall survival of approximately 3 years.

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头颈部复发性皮肤鳞状细胞癌在明确手术和放射治疗后的挽救性手术的结果。

目的：描述有头颈部皮肤鳞状细胞癌（cSCC）病史的患者既往接受明确手术和放疗（RT）治疗后，因疾病复发而行补救性手术的结果。关于这组患者的资料很少。方法：回顾性研究。回顾了2003年至2022年间评估为头颈部晚期cSCC的患者。那些有手术和辅助放疗史的患者因复发而接受挽救性手术，被纳入主要队列。比较了接受初级/初始治疗的患者，以及接受复发手术但没有辅助放疗史的患者。结果：在579例患者中，49例符合主要队列的纳入标准。平均随访时间22个月。19例（38.8%）复发，均在术后14个月内。在分期为T2b或T3的患者中，复发率为50%。术后平均总生存期为35.6个月（95% CI = 24.7-46.4）。结论：该队列患者复发率高，总生存期约为3年。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Otology Rhinology and Laryngology 医学-耳鼻喉科学

CiteScore

3.10

自引率

7.10%

发文量

171

审稿时长

4-8 weeks

期刊介绍： The Annals of Otology, Rhinology & Laryngology publishes original manuscripts of clinical and research importance in otolaryngology–head and neck medicine and surgery, otology, neurotology, bronchoesophagology, laryngology, rhinology, head and neck oncology and surgery, plastic and reconstructive surgery, pediatric otolaryngology, audiology, and speech pathology. In-depth studies (supplements), papers of historical interest, and reviews of computer software and applications in otolaryngology are also published, as well as imaging, pathology, and clinicopathology studies, book reviews, and letters to the editor. AOR is the official journal of the American Broncho-Esophagological Association.