Intradural extramedullary eosinophilic granuloma of the spine with emergency presentation: A case report.

Surgical neurology international Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI:10.25259/SNI_581_2024

Wamedh Esam Matti, Hussain J Kadhum, Ibtisam Hussein Al Obaidi, Maher Khashea Mustafa, Ahmed Maan Taha Mustafa, Rasha Alaa Alshakarchy, Mustafa Ismail

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Abstract

Background: Intradural extramedullary spinal eosinophilic granuloma is a very unusual manifestation of Langerhans Cell Histiocytosis (LCH) that is typically misdiagnosed due to its nonspecific clinical and radiological features.

Case description: We report a case of a 22-year-old female patient who presented with acute onset paraplegia. The magnetic resonance imaging was initially suggestive of tuberculoma, which is prevalent in tuberculosis-endemic regions. Intraoperative findings and histopathology, however, established the diagnosis of LCH. The lesion was intradural, and CD1a and S-100 protein staining demonstrated classic Langerhans cells.

Conclusion: The paper stresses the need for a multidisciplinary team in the proper diagnosis and handling of spinal LCH. Further research is needed to develop optimal management protocols for this rare condition.

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脊柱硬膜内髓外嗜酸性肉芽肿急诊1例。

背景：脊髓硬膜内髓外嗜酸性肉芽肿是朗格汉斯细胞组织细胞增多症（LCH）的一种非常罕见的表现，由于其非特异性的临床和影像学特征，通常被误诊。病例描述：我们报告一个22岁的女性患者谁提出急性发作截瘫。磁共振成像最初提示结核瘤，这是普遍存在于结核病流行地区。然而，术中发现和组织病理学确定了LCH的诊断。病变位于硬膜内，CD1a和S-100蛋白染色显示典型朗格汉斯细胞。结论：本文强调在正确诊断和处理脊柱LCH时需要一个多学科的团队。需要进一步的研究来制定这种罕见疾病的最佳管理方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Surgical neurology international

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