Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation.

IF 8.2 2区生物学 Q1 CELL BIOLOGY

Cell Communication and Signaling Pub Date : 2025-04-18 DOI:10.1186/s12964-025-02194-z

Zhiyao Yuan, Paul A Janmey, Christopher A McCulloch

引用次数: 0

Abstract

The canonical functions of vimentin in cell mechanics and migration have been recently expanded by the discovery of new roles for extracellular vimentin (ECV) in immune responses to infection, injury and cancer. In contrast with the predominantly filamentous form of intracellular vimentin, ECV exists largely as soluble oligomers. The release of ECV from intact cells is dependent on mechanisms that regulate the assembly and disassembly of intracellular vimentin, which are influenced by discrete post-translational modifications. In this review we highlight the processes that promote the conversion of intracellular and insoluble vimentin filaments to ECV and secretion mechanisms. Insights into the regulation of ECV release from stromal and immune cells could provide new diagnostic and therapeutic approaches for assessing and controlling inflammatory diseases.

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炎症反应中细胞外波形蛋白生成和分泌过程中波形蛋白的结构和功能。

最近，细胞外波形蛋白（ECV）在感染、损伤和癌症的免疫应答中的新作用的发现，扩大了波形蛋白在细胞力学和迁移中的典型功能。与主要呈丝状的细胞内波形蛋白相比，ECV主要以可溶性低聚物的形式存在。完整细胞中ECV的释放依赖于调节细胞内vimentin组装和拆卸的机制，而这一机制受到离散的翻译后修饰的影响。在这篇综述中，我们重点介绍了促进细胞内和不溶性静脉蛋白丝向ECV转化的过程和分泌机制。了解基质细胞和免疫细胞释放ECV的调控可以为评估和控制炎症性疾病提供新的诊断和治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.