Treatment of severe pain in a patient with a cervical spinal cord injury at C5-7 level using an intrathecal targeted drug delivery system - A case report.

Anesthesia and pain medicine Pub Date : 2025-04-01 Epub Date: 2025-04-30 DOI:10.17085/apm.24151
Yeong-Min Yoo, Ji-Eun Jung, Hyun-Jin Kim, Hyeon-Soo Park, Hye-Jin Kim, Gyeong-Jo Byeon
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引用次数: 0

Abstract

Background: Patients with cervical spinal cord injury (SCI) can experience pain refractory to aggressive multimodal therapies. Here, we report the use of an intrathecal targeted drug delivery (ITDD) system to treat severe pain in patients with cervical SCI.

Case: A 64-year-old male patient underwent spinal cord stimulation (SCS) for severe cervical SCI. We proceeded with the ITDD system, placing the catheter tip at the C6 level. After placement of the ITDD system, the patient was monitored for regular refills of morphine sulfate in the drug delivery reservoir every 6 months. We reduced the oral morphine equivalent dose from nearly 333.8 mg/day to 133.8 mg/day.

Conclusions: The ITDD system may be a useful treatment option for patients with cervical SCI who have failed conventional treatments and do not show improvement with SCS.

鞘内靶向给药系统治疗C5-7节段颈脊髓损伤患者剧烈疼痛1例报告
背景:颈椎脊髓损伤(SCI)患者可以经历对积极的多模式治疗难以治愈的疼痛。在这里,我们报告使用鞘内靶向给药(ITDD)系统来治疗颈椎脊髓损伤患者的严重疼痛。病例:一名64岁男性患者因严重颈椎损伤接受脊髓刺激(SCS)治疗。我们继续使用ITDD系统,将导管尖端置于C6水平。放置ITDD系统后,监测患者每6个月在给药库中定期补充硫酸吗啡。我们将口服吗啡当量剂量从近333.8 mg/天减少到133.8 mg/天。结论:ITDD系统可能是一种有效的治疗选择,对于那些常规治疗失败且SCS没有改善的颈椎脊髓损伤患者。
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CiteScore
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