Angiopoietin-Like Protein Family-Mediated Functions in Modulating Triglyceride Metabolism and Related Metabolic Diseases.

IF 3.3 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-31 DOI:10.31083/FBL25862

Sen Yang, Xin Su, Min Lai, Xiaoxi Liu, Ye Cheng

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Abstract

Hypertriglyceridemia, characterized by increased triglyceride (TG) concentrations, is considered the most important risk factor for cardiometabolic disorders, including dyslipidemia, atherosclerotic cardiovascular diseases, and non-alcoholic fatty liver disease (NAFLD). Recently, the angiopoietin-like protein (ANGPTL) family, which comprises ANGPTL1 to ANGPTL8, was confirmed to play an important role in modulating lipoprotein lipase (LPL) activity. However, understanding of the underlying mechanisms remains limited. Importantly, emerging evidence has linked several transcriptional and post-transcriptional factors to the potential alteration of TG metabolism via ANGPTL proteins. This review focused on the similarities and differences in the expression, structural features, and modulatory profile of three ANGPTLs: ANGPTL3, ANGPTL4, and ANGPTL8. In addition, the regulatory functions of those three ANGPTLs in modulating LPL were summarized to provide potential therapeutic and clinical strategies for hypertriglyceridemia and its related cardiometabolic disorders.

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血管生成素样蛋白家族介导的调节甘油三酯代谢和相关代谢疾病的功能

以甘油三酯（TG）浓度升高为特征的高甘油三酯血症被认为是包括血脂异常、动脉粥样硬化性心血管疾病和非酒精性脂肪性肝病（NAFLD）在内的心脏代谢紊乱的最重要危险因素。近年来，血管生成素样蛋白（ANGPTL）家族，包括ANGPTL1至ANGPTL8，被证实在调节脂蛋白脂肪酶（LPL）活性中起重要作用。然而，对其潜在机制的理解仍然有限。重要的是，新出现的证据表明，一些转录和转录后因素与通过ANGPTL蛋白改变TG代谢的潜在可能性有关。本文综述了ANGPTL3、ANGPTL4和ANGPTL8三种ANGPTL3在表达、结构特征和调控方面的异同。此外，本文还总结了这三种angptl在调节LPL中的调节功能，以期为高甘油三酯血症及其相关心脏代谢疾病的治疗和临床提供潜在的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in bioscience (Landmark edition)

CiteScore

3.50

自引率

0.00%

发文量