Depression, Subjective Health, Obesity, and Multimorbidity are Associated with Epigenetic Age Acceleration.

Journal of biomedical and life sciences Pub Date : 2025-01-01 Epub Date: 2025-04-03 DOI:10.31586/jbls.2025.6041
Shervin Assari, John Ashley Pallera
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Abstract

Background: Epigenetic aging, measured through various DNA methylation-based clocks, may have implications for predicting disease risk. However, the sensitivity of different epigenetic clocks that have emerged as biomarkers for biological aging and in predicting physical and mental health outcomes remains uncertain. This study examines the age and sex-adjusted associations between multiple epigenetic age acceleration measures and three key health indicators, including self-rated health, depressive symptoms, and body mass index (BMI), in a nationally representative sample of U.S. middle-aged and older adults.

Methods: We analyzed data from 4,018 adults in the 2016 wave of the Health and Retirement Study (HRS), which included several epigenetic age acceleration measures: HORVATH, HANNUM, LEVINE, HORVATHSKIN, LIN, WEIDNER, VIDALBRALO, YANG, ZHANG, BOCKLANDT, GARAGNANI, and GRIMAGE. Linear regression models were used to assess the associations between epigenetic age acceleration and self-rated health (poor health), depressive symptoms, and BMI, adjusting for age and sex.

Results: We found significant positive associations between epigenetic age acceleration and worse self-rated health, higher depressive symptoms, and increased BMI. However, these associations varied across different epigenetic clocks, with some measures potentially having more consistent utility for specific health outcomes than others.

Conclusion: Epigenetic age acceleration is linked to poorer self-rated health, greater depressive symptoms, and higher BMI, but choosing which epigenetic clock(s) to use is also important. These findings underscore the need to consider multiple epigenetic aging markers when assessing health risks and highlight the potential for particular clocks to serve as more sensitive indicators of physical and mental health outcomes.

抑郁、主观健康、肥胖和多病与表观遗传年龄加速有关。
背景:通过各种基于DNA甲基化的时钟测量表观遗传衰老,可能对预测疾病风险有影响。然而,作为生物衰老和预测身心健康结果的生物标志物的不同表观遗传时钟的敏感性仍然不确定。本研究考察了多种表观遗传年龄加速测量与三个关键健康指标之间的年龄和性别调整的关联,包括自评健康、抑郁症状和体重指数(BMI),研究对象为美国中老年成年人的全国代表性样本。方法:我们分析了2016年健康与退休研究(HRS)浪潮中4,018名成年人的数据,其中包括几种表观遗传年龄加速措施:HORVATH、HANNUM、LEVINE、HORVATHSKIN、LIN、WEIDNER、VIDALBRALO、YANG、ZHANG、BOCKLANDT、GARAGNANI和GRIMAGE。线性回归模型用于评估表观遗传年龄加速与自评健康(健康状况不佳)、抑郁症状和BMI之间的关系,并对年龄和性别进行了调整。结果:我们发现表观遗传年龄加速与自我评价健康状况恶化、抑郁症状加重和BMI增加之间存在显著的正相关。然而,这些关联在不同的表观遗传时钟中有所不同,有些测量方法可能比其他方法对特定的健康结果具有更一致的效用。结论:表观遗传年龄加速与自我评价较差的健康状况、更严重的抑郁症状和更高的BMI有关,但选择使用哪种表观遗传时钟也很重要。这些发现强调了在评估健康风险时考虑多种表观遗传衰老标记的必要性,并强调了特定时钟作为生理和心理健康结果更敏感指标的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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