Coilin Is Not Expressed by Immunohistochemistry in Hodgkin and Diffuse Large B-cell Lymphomas.

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY
Georgia Karpathiou, Mousa Mobarki, Shaqraa Musawi, Alexandra Papoudou-Bai, Michel Péoc'h
{"title":"Coilin Is Not Expressed by Immunohistochemistry in Hodgkin and Diffuse Large B-cell Lymphomas.","authors":"Georgia Karpathiou, Mousa Mobarki, Shaqraa Musawi, Alexandra Papoudou-Bai, Michel Péoc'h","doi":"10.1097/PAI.0000000000001259","DOIUrl":null,"url":null,"abstract":"<p><p>Coilin is the signature protein of Cajal bodies (CBs), membrane-less organelles probably acting as sites for post-transcriptional RNA modification. Recent data suggest that coilin may be a regulator of the NF-kB activity, and Hodgkin lymphomas are hallmarks of neoplasms with NF-kB dysregulation. To the best of our knowledge, the immunohistochemical expression of coilin has been never investigated in Hodgkin lymphomas. We herein examined, by immunohistochemistry, full tissue sections of 58 classical Hodgkin lymphomas diagnosed in 31 male and 27 female patients and found that none of the cases expressed coilin. We compared these findings with Coilin expression in diffuse large B-cell lymphomas (DLBCL), where the marker was also negative. This finding represents the first data on coilin in lymphomas and prompts further studies to explore this downregulation.</p>","PeriodicalId":48952,"journal":{"name":"Applied Immunohistochemistry & Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Immunohistochemistry & Molecular Morphology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/PAI.0000000000001259","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Coilin is the signature protein of Cajal bodies (CBs), membrane-less organelles probably acting as sites for post-transcriptional RNA modification. Recent data suggest that coilin may be a regulator of the NF-kB activity, and Hodgkin lymphomas are hallmarks of neoplasms with NF-kB dysregulation. To the best of our knowledge, the immunohistochemical expression of coilin has been never investigated in Hodgkin lymphomas. We herein examined, by immunohistochemistry, full tissue sections of 58 classical Hodgkin lymphomas diagnosed in 31 male and 27 female patients and found that none of the cases expressed coilin. We compared these findings with Coilin expression in diffuse large B-cell lymphomas (DLBCL), where the marker was also negative. This finding represents the first data on coilin in lymphomas and prompts further studies to explore this downregulation.

免疫组织化学未发现Coilin在霍奇金淋巴瘤和弥漫性大b细胞淋巴瘤中表达。
Coilin是Cajal小体(CBs)的特征蛋白,无膜细胞器可能作为转录后RNA修饰的位点。最近的数据表明,coilin可能是NF-kB活性的调节因子,而霍奇金淋巴瘤是NF-kB失调肿瘤的标志。据我们所知,从未研究过在霍奇金淋巴瘤中肠溶蛋白的免疫组织化学表达。在此,我们通过免疫组织化学检查了58例典型霍奇金淋巴瘤的全组织切片,其中31例男性和27例女性,发现没有一例表达结肠蛋白。我们将这些发现与Coilin在弥漫性大b细胞淋巴瘤(DLBCL)中的表达进行了比较,后者也是阴性。这一发现代表了首个关于coilin在淋巴瘤中的数据,并促使进一步研究探索这种下调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信