Georgia Karpathiou, Mousa Mobarki, Shaqraa Musawi, Alexandra Papoudou-Bai, Michel Péoc'h
{"title":"Coilin Is Not Expressed by Immunohistochemistry in Hodgkin and Diffuse Large B-cell Lymphomas.","authors":"Georgia Karpathiou, Mousa Mobarki, Shaqraa Musawi, Alexandra Papoudou-Bai, Michel Péoc'h","doi":"10.1097/PAI.0000000000001259","DOIUrl":null,"url":null,"abstract":"<p><p>Coilin is the signature protein of Cajal bodies (CBs), membrane-less organelles probably acting as sites for post-transcriptional RNA modification. Recent data suggest that coilin may be a regulator of the NF-kB activity, and Hodgkin lymphomas are hallmarks of neoplasms with NF-kB dysregulation. To the best of our knowledge, the immunohistochemical expression of coilin has been never investigated in Hodgkin lymphomas. We herein examined, by immunohistochemistry, full tissue sections of 58 classical Hodgkin lymphomas diagnosed in 31 male and 27 female patients and found that none of the cases expressed coilin. We compared these findings with Coilin expression in diffuse large B-cell lymphomas (DLBCL), where the marker was also negative. This finding represents the first data on coilin in lymphomas and prompts further studies to explore this downregulation.</p>","PeriodicalId":48952,"journal":{"name":"Applied Immunohistochemistry & Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Immunohistochemistry & Molecular Morphology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/PAI.0000000000001259","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Coilin is the signature protein of Cajal bodies (CBs), membrane-less organelles probably acting as sites for post-transcriptional RNA modification. Recent data suggest that coilin may be a regulator of the NF-kB activity, and Hodgkin lymphomas are hallmarks of neoplasms with NF-kB dysregulation. To the best of our knowledge, the immunohistochemical expression of coilin has been never investigated in Hodgkin lymphomas. We herein examined, by immunohistochemistry, full tissue sections of 58 classical Hodgkin lymphomas diagnosed in 31 male and 27 female patients and found that none of the cases expressed coilin. We compared these findings with Coilin expression in diffuse large B-cell lymphomas (DLBCL), where the marker was also negative. This finding represents the first data on coilin in lymphomas and prompts further studies to explore this downregulation.
期刊介绍:
Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist.
Official Journal of the International Society for Immunohistochemisty and Molecular Morphology.