A Reassessment of Chorionic Histiocytic Hyperplasia in Association With Other Inflammatory Lesions of the Placenta.

IF 1.3 4区医学 Q3 PATHOLOGY

Pediatric and Developmental Pathology Pub Date : 2025-09-01 Epub Date: 2025-04-24 DOI:10.1177/10935266251337135

Philip J Katzman, Leon A Metlay

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引用次数: 0

Abstract

Background: Chorionic histiocytic hyperplasia (CHH) is a chronic inflammatory lesion (CIL) with a linear infiltrate of fetal histiocytes in the base of fetal or membranous chorion. We performed a retrospective study of placentas diagnosed since our last study period in order to analyze the strength of the association of CHH with other CIL.

Methods: Third trimester placentas diagnosed with CHH were identified in our LIS. Comparisons of incidence of associated lesions, including chronic villitis (CV), chronic deciduitis (CD), chronic chorioamnionitis (CC), eosinophilic/T-cell chorionic vasculitis (ETCV), and maternal and fetal acute inflammatory responses, between the prior and current studies were evaluated using the chi square statistic.

Results: CHH was present in 2.2% of placentas, significantly higher than 1.3% in the prior study period. A majority of CHH cases had accompanying CV (82.3%). CD was more often associated with CHH in the current study than in the prior study (49.1% vs 40.0%).

Conclusions: The greater incidence of CHH in third trimester placentas diagnosed in the past 7.5 years may be due to greater recognition of the lesion by our pathologists. This study demonstrated the need for more research of CIL.

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绒毛膜组织细胞增生与胎盘其他炎性病变的相关性再评估。

背景：绒毛膜组织细胞增生（CHH）是一种慢性炎性病变（CIL），胎儿组织细胞在胎儿或膜绒毛膜基部呈线性浸润。我们对上一次研究以来诊断的胎盘进行了回顾性研究，以分析CHH与其他CIL的关联强度。方法：在我们的LIS中发现诊断为CHH的妊娠晚期胎盘。比较既往和当前研究中相关病变的发生率，包括慢性绒毛炎（CV）、慢性蜕膜炎（CD）、慢性绒毛膜羊膜炎（CC）、嗜酸性/ t细胞绒毛膜血管炎（ETCV）以及母体和胎儿的急性炎症反应，使用卡方统计进行评估。结果：2.2%的胎盘中存在CHH，显著高于之前研究期间的1.3%。大多数CHH病例伴有CV（82.3%）。与先前的研究相比，本研究中CD更常与CHH相关（49.1% vs 40.0%）。结论：在过去的7.5年中，晚期妊娠胎盘CHH的发病率较高，可能是由于我们的病理学家对这种病变的认识更高。本研究表明需要对CIL进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric and Developmental Pathology 医学-病理学

CiteScore

3.70

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.