Jesús Daniel Meléndez-Flores, Mónica Sánchez-Cárdenas
{"title":"Inappropriate prescription of loop diuretics for calcium channel blocker-related peripheral edema: Lessons from physiology.","authors":"Jesús Daniel Meléndez-Flores, Mónica Sánchez-Cárdenas","doi":"10.1016/j.amjms.2025.04.015","DOIUrl":null,"url":null,"abstract":"<p><p>Calcium Channel Blockers (CCB) are commonly used antihypertensive agents, with peripheral edema being a common side effect, reported in up to 70 % of cases. A common pitfall among physicians is that they consider this fluid overload, with some prescribing loop diuretics. Nonetheless, this might lead to several complications, such as electrolyte abnormalities and acute kidney injury, among others. In this article, we describe the main mechanisms of the vasodilatory and diuretic-resistant edema of CCB and suggest several strategies that might aid physicians in reducing this side effect.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The American journal of the medical sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.amjms.2025.04.015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Calcium Channel Blockers (CCB) are commonly used antihypertensive agents, with peripheral edema being a common side effect, reported in up to 70 % of cases. A common pitfall among physicians is that they consider this fluid overload, with some prescribing loop diuretics. Nonetheless, this might lead to several complications, such as electrolyte abnormalities and acute kidney injury, among others. In this article, we describe the main mechanisms of the vasodilatory and diuretic-resistant edema of CCB and suggest several strategies that might aid physicians in reducing this side effect.
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