Is Aneuploidy a Consistent Marker for Malignant Transformation Risk in Oral Lichen Planus?

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2025-05-08 DOI:10.1007/s12105-025-01779-x

Aya Pessing-Shabi, Ayelet Zlotogorski-Hurvitz, Noam Yarom, Ilana Kaplan, Luba Trakhtenbrot, Abraham Hirshberg

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引用次数: 0

Abstract

Background: Numeric chromosomal imbalance, known as aneuploidy, is linked to both malignant and potentially malignant epithelial lesions. Aneuploidy has also been investigated in oral potentially malignant disorders (OPMDs) due to its high incidence in head and neck cancers, particularly in oral squamous cell carcinoma (OSCC). The study aimed to evaluate the potential of aneuploidy, a marker of chromosomal imbalance, as a prognostic tool for assessing malignant transformation risk in oral lichen planus (OLP) patients.

Methods: Fluorescent in situ hybridization (FISH) analysis targeting centromeric probes for chromosomes 2 and 8 was conducted on samples from 245 patients, with follow-up in 135 cases.

Results: Aneuploid cells (ACs) were detected in 73 patients (29.8%); 24 (32.9%) exhibited non-diploid cells in a normal looking mucosa. Only 2 (0.8%) patients developed OSCC during the follow-up. Among the 135 followed, 11 (8.1%) were positive for Acs in both samples, 15 (11.1%) were were negative initially but positive later. In contrast, 3 patients (2.2%) were initially positive but later negative.

Conclusion: These results indicate a low malignant transformation rate (< 1%), despite a high rate of aneuploidy. These also demonstrate variability in aneuploidy results over time. The dynamic nature of aneuploidy observed suggests that it may not be a reliable predictive tool for malignant transformation in OLP.

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非整倍体是口腔扁平苔藓恶性转化风险的一致标志吗？

背景：染色体数量失衡，被称为非整倍体，与恶性和潜在恶性上皮病变有关。由于非整倍体在头颈部癌症，特别是口腔鳞状细胞癌（OSCC）中的高发病率，因此也对口腔潜在恶性疾病（OPMDs）进行了研究。该研究旨在评估非整倍体（染色体失衡的标志）作为评估口腔扁平苔藓（OLP）患者恶性转化风险的预后工具的潜力。方法：对245例患者进行2、8号染色体着丝粒探针荧光原位杂交（FISH）分析，并对135例患者进行随访。结果：73例患者检出非整倍体细胞（ACs），占29.8%；24例（32.9%）表现为非二倍体细胞。随访期间，仅有2例（0.8%）患者出现OSCC。在随访的135例样本中，11例（8.1%）均为Acs阳性，15例（11.1%）为初始阴性后阳性。相反，3例（2.2%）患者最初呈阳性，后来呈阴性。结论：肿瘤恶性转化率低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.