[Analysis of retinopathy of prematurity screening outcomes in a neonatal intensive care unit of Lhasa].

Q3 Medicine
X M Zhu, Q B Ye, H Y Long, B C R Ciren, Z Yu, T Y Han, J H Liang
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引用次数: 0

Abstract

Objective: To investigate the incidence and clinical features of retinopathy of prematurity (ROP) among preterm infants in a neonatal intensive care unit (NICU) of Lhasa, and to explore the screening criteria for ROP in high-altitude areas. Methods: It was a single-center retrospective case study. A total of 166 preterm infants of Tibetan ethnicity admitted to the NICU of Lhasa People's Hospital from May 1, 2020 to June 1, 2022 with a gestational age<36 weeks were enrolled. ROP was screened using the third-generation wide-angle digital pediatric retinal imaging system (RetCam Ⅲ). The ROP detection rate, staging, and zonal distribution were analyzed. Multivariate logistic regression was performed and risk factors for ROP in preterm infants were identified by calculating the odds ratio (OR) and its 95% confidence interval (95%CI). Results: There were 88 males and 78 females, among whom 33 patients (66 eyes) were diagnosed with ROP. The birth gestational age of ROP patients was 30 (29, 31) weeks, and the average birth weight was 1 188.5±219.2 g. The disease was at stage 1 in 48 eyes (72.7%), stage 2 in 16 eyes (24.2%), and stage 3 in 2 eyes (3.0%). Two eyes (3.0%) had zone Ⅰ disease, 26 eyes (39.4%) had zone Ⅱ disease, and 38 eyes (57.6%) had zone Ⅲ disease. Thirty ROP patients (90.9%) had spontaneous regression and vascularization. Three patients (9.1%) developed type Ⅰ ROP, which was treated by anti-VEGF therapy (1 patient) or spontaneously resolved during the follow-up (2 patients). Multiple logistic regression analysis showed that gestational age (OR=0.53, 95%CI: 0.33-0.84, P=0.007), birth weight (OR=0.95, 95%CI: 0.92-0.98, P<0.001), and duration of invasive mechanical ventilation (OR=1.42, 95%CI: 1.06-1.90, P=0.018) were influencing factors of ROP. Conclusions: The detection rate of ROP among Tibetan preterm infants in the single-center neonatal intensive care unit in Lhasa was 19.9%, while the detection rate of type Ⅰ ROP was 1.8%. Preterm infants with shorter gestational age, lower birth weight, and prolonged invasive mechanical ventilation were liable to develop ROP.

[拉萨1例新生儿重症监护病房早产儿视网膜病变筛查结果分析]。
目的:了解拉萨市某新生儿重症监护病房(NICU)早产儿视网膜病变(ROP)的发病率及临床特点,探讨高海拔地区早产儿视网膜病变的筛查标准。方法:采用单中心回顾性病例研究。2020年5月1日至2022年6月1日在拉萨市人民医院新生儿重症监护病房(NICU)住院的166例藏族早产儿,胎龄(or)及其95%可信区间(95% ci)。结果:男性88例,女性78例,确诊ROP 33例(66眼)。ROP患者的出生胎龄为30(29,31)周,平均出生体重为1 188.5±219.2 g。48只眼睛处于1期(72.7%),16只眼睛处于2期(24.2%),2只眼睛处于3期(3.0%)。Ⅰ区病变2眼(3.0%),Ⅱ区病变26眼(39.4%),Ⅲ区病变38眼(57.6%)。30例ROP患者(90.9%)出现自发消退和血管化。3例(9.1%)发生Ⅰ型ROP,经抗vegf治疗(1例)或随访中自行消退(2例)。多因素logistic回归分析显示,胎龄(OR=0.53, 95%CI: 0.33 ~ 0.84, P=0.007)、出生体重(OR=0.95, 95%CI: 0.92 ~ 0.98, POR=1.42, 95%CI: 1.06 ~ 1.90, P=0.018)是影响ROP的因素。结论:拉萨市单中心新生儿重症监护病房藏族早产儿ROP检出率为19.9%,Ⅰ型ROP检出率为1.8%。短胎龄、低出生体重、长时间有创机械通气的早产儿易发生ROP。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
中华眼科杂志
中华眼科杂志 Medicine-Ophthalmology
CiteScore
0.80
自引率
0.00%
发文量
12700
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