Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes.

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2025-04-15 DOI:10.4239/wjd.v16.i4.101966

Rui Wang, Yu-Xian Xu, Feng Xu, Chun-Hua Wang, Li-Hua Zhao, Li-Hua Wang, Wei-Guan Chen, Xue-Qin Wang, Cheng-Wei Duan, Jian-Bin Su

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Abstract

Background: Increased blood urea nitrogen (BUN) levels have been demonstrated to be associated with broader metabolic disturbances and the incidence of type 2 diabetes (T2D), potentially playing a role in the development of diabetic complications, including diabetic peripheral neuropathy.

Aim: To examine the relationship between BUN levels and peripheral nerve function in patients with T2D.

Methods: This observational study involved the systematic recruitment of 585 patients with T2D for whom BUN levels and estimated glomerular filtration rate were measured. Electromyography was used to assess peripheral motor and sensory nerve function in all patients, and overall composite Z-scores were subsequently calculated for nerve latency, amplitude, and conduction velocity (NCV) across the median, ulnar, common peroneal, posterior tibial, superficial peroneal, and sural nerves.

Results: Across the quartiles of BUN levels, the overall composite Z-score for latency (F = 38.996, P for trend < 0.001) showed a significant increasing trend, whereas the overall composite Z-scores for amplitude (F = 50.972, P for trend < 0.001) and NCV (F = 30.636, P for trend < 0.001) exhibited a significant decreasing trend. Moreover, the BUN levels were closely correlated with the latency, amplitude, and NCV of each peripheral nerve. Furthermore, multivariate linear regression analysis revealed that elevated BUN levels were linked to a higher overall composite Z-score for latency (β = 0.166, t = 3.864, P < 0.001) and lower overall composite Z-scores for amplitude (β = -0.184, t = -4.577, P < 0.001) and NCV (β = -0.117, t = -2.787, P = 0.006) independent of the estimated glomerular filtration rate and other clinical covariates. Additionally, when the analysis was restricted to sensory or motor nerves, elevated BUN levels remained associated with sensory or motor peripheral nerve dysfunction.

Conclusion: Increased BUN levels were independently associated with compromised peripheral nerve function in patients with T2D.

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2型糖尿病患者血尿素氮水平升高和周围神经功能受损

背景：血液尿素氮（BUN）水平升高已被证明与更广泛的代谢紊乱和2型糖尿病（T2D）的发病率相关，可能在糖尿病并发症的发展中起作用，包括糖尿病周围神经病变。目的：探讨t2dm患者外周血BUN水平与周围神经功能的关系。方法：本观察性研究系统招募了585例T2D患者，测量了BUN水平和估计的肾小球滤过率。使用肌电图评估所有患者的外周运动和感觉神经功能，随后计算正中神经、尺神经、腓总神经、胫后神经、腓浅神经和腓肠神经的神经潜伏期、振幅和传导速度（NCV）的综合z分数。结果：在BUN水平的四分位数中，潜伏期综合z得分（F = 38.996， P为趋势< 0.001）呈显著上升趋势，振幅综合z得分（F = 50.972， P为趋势< 0.001）和NCV综合z得分（F = 30.636， P为趋势< 0.001）呈显著下降趋势。此外，BUN水平与各周围神经潜伏期、振幅和NCV密切相关。此外，多元线性回归分析显示，BUN水平升高与潜伏期总体复合z -评分（β = 0.166, t = 3.864, P < 0.001）和振幅总体复合z -评分（β = -0.184, t = -4.577, P < 0.001）和NCV （β = -0.117, t = -2.787, P = 0.006）相关，与肾小球滤过率和其他临床变量无关。此外，当分析仅限于感觉或运动神经时，BUN水平升高仍与感觉或运动周围神经功能障碍有关。结论：BUN水平升高与T2D患者周围神经功能受损独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.