RISK FACTORS FOR RENAL CALCULI IN PATIENTS WITH CROHN'S DISEASE.

Q2 Medicine
Arquivos de Gastroenterologia Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI:10.1590/S0004-2803.24612024-023
Dídia Bismara Cury, Liana Cristina Bismara Cury, Ana Camila Michelletti, Rogerio Antonio Oliveira, Elsa Alidia Petry Gonçalves, Nestor Schor
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引用次数: 0

Abstract

Background: The incidence of nephrolithiasis has increased significantly, diet, obesity, and high animal protein intake having been reported to be risk factors. Nephrolithiasis has a great economic impact on society related to work absenteeism, recurrent attacks of renal colic, and urological interventions. Nephrolithiasis can also progress to renal failure. It is therefore important to identify the risk factors for nephrolithiasis. Inflammatory bowel diseases, which include Crohn's disease, represent a risk factor for the formation of renal calculi, due to the disease itself and to the use of drugs that can influence the metabolism of substances related to nephrolithiasis. In the past, Crohn's disease patients were often submitted to surgery, which is known to contribute to nephrolithiasis. New drugs have changed the clinical course of Crohn's disease, whose incidence has increased worldwide. Specialists should be on the alert not only for the complications of Crohn's disease but also for its extraintestinal manifestations, which can dramatically affect the quality of life of these patients and lead to renal failure. It is therefore important to screen this population for nephrolithiasis.

Objective: To determine the prevalence of nephrolithiasis in a population of patients with Crohn's disease; to determine whether drugs, previous surgery, location of the disease, and clinical activity are risk factors for nephrolithiasis; and to alert specialists to the importance of screening for nephrolithiasis (through simple methods) in order to prevent chronic kidney disease.

Methods: Were analyzed the electronic medical records of 93 Crohn's disease patients treated between 2009 and 2010 at the Inflammatory Bowel Disease Center of the Scope Clinic, located in the city of Campo Grande. All of the patients underwent ultrasound at the first medical appointment.

Results: Of the 93 patients, 37 developed nephrolithiasis at some point during the study period. Risk factors for nephrolithiasis were disease location (P=0.023) and the use of ciprofloxacin (P=0.0001), corticosteroids (P=0.005), immunomodulators (P=0.001), or metronidazole (P=0.0005). Surgical status, age, and gender were not found to predispose to the formation of renal calculi.

Conclusion: This study demonstrates the importance of using imaging methods to screen Crohn's disease patients for nephrolithiasis, regardless of their surgical status.

克罗恩病患者肾结石的危险因素
背景:肾结石的发病率显著增加,饮食、肥胖和高动物蛋白摄入已被报道为危险因素。肾结石对社会有很大的经济影响,与旷工、肾绞痛复发和泌尿外科干预有关。肾结石也可发展为肾衰竭。因此确定肾结石的危险因素是很重要的。炎症性肠病,包括克罗恩病,是肾结石形成的一个危险因素,因为疾病本身和使用的药物可以影响肾结石相关物质的代谢。过去,克罗恩病患者经常接受手术治疗,这是已知的导致肾结石的原因。新的药物已经改变了克罗恩病的临床进程,其发病率在世界范围内有所增加。专家们不仅要警惕克罗恩病的并发症,还要警惕它的肠外表现,这可能会极大地影响这些患者的生活质量,并导致肾功能衰竭。因此,对这些人群进行肾结石筛查是很重要的。目的:了解克罗恩病患者肾结石的患病率;确定药物、既往手术、疾病位置和临床活动是否为肾结石的危险因素;并提醒专家注意(通过简单的方法)筛查肾结石的重要性,以预防慢性肾脏疾病。方法:分析2009年至2010年在坎波格兰德市Scope诊所炎症性肠病中心治疗的93例克罗恩病患者的电子病历。所有患者在第一次医疗预约时都接受了超声波检查。结果:93例患者中,37例在研究期间发生肾结石。肾结石的危险因素是疾病部位(P=0.023)和使用环丙沙星(P=0.0001)、皮质类固醇(P=0.005)、免疫调节剂(P=0.001)或甲硝唑(P=0.0005)。未发现手术状态、年龄和性别易导致肾结石的形成。结论:本研究证明了使用影像学方法筛查克罗恩病患者肾结石的重要性,无论其手术状态如何。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Arquivos de Gastroenterologia
Arquivos de Gastroenterologia Medicine-Gastroenterology
CiteScore
2.00
自引率
0.00%
发文量
109
审稿时长
9 weeks
期刊介绍: The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.
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