Organoid models in bladder cancer: From bench to bedside?

IF 1 4区 医学 Q4 ONCOLOGY
Bladder Cancer Pub Date : 2025-04-17 eCollection Date: 2025-04-01 DOI:10.1177/23523735251330404
Hongda Zhao, Vincy Wing Sze Ho, Kang Liu, Xuan Chen, Hongwei Wu, Peter Ka-Fung Chiu, Lu-Yan Chan, Steffi Kar-Kei Yuen, David Ka-Wai Leung, Alex Qinyang Liu, Chris Ho-Ming Wong, Ivan Ching-Ho Ko, Chi Fai Ng, Dinglan Wu, Jeremy Yuen-Chun Teoh
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引用次数: 0

Abstract

Background: Bladder cancer (BC), one of the most prevalent and aggressive urological malignancies, poses significant challenges in diagnosis, treatment, and recurrence management. Patient-derived organoid provides new directions for the precision diagnosis and treatment of bladder cancer.

Objective: To make a comprehensive summary of the current bladder cancer organoid studies.

Methods: A comprehensive database search was conducted to provide an in-depth overview of the current state of bladder cancer organoid models, with a focus on their applications in basic research, clinical translation, and therapeutic discovery.

Results: We summarized the current bladder cancer organoid studies, highlighting their advantages, such as genetic fidelity and high-throughput drug screening capabilities. Additionally, we also address the challenges, including their limited representation of the tumour microenvironment and technical complexity. Finally, we discuss future directions, including the integration of immunotherapy, the development of co-culture systems, and the exploration of non-invasive sampling methods and organoid-on-chip systems.

Conclusions: Traditional pre-clinical models have inherent limitations in mimicking the complexity of human tumours. The emergence of organoid technology has offered a groundbreaking approach to address this challenge, providing an innovative tool for studying tumour biology, genetic alterations, drug screening, and personalized medicine in bladder cancer.

膀胱癌的类器官模型:从实验到临床?
背景:膀胱癌(膀胱癌)是泌尿系统最常见和侵袭性的恶性肿瘤之一,在诊断、治疗和复发管理方面提出了重大挑战。患者源性类器官为膀胱癌的精准诊断和治疗提供了新的方向。目的:全面总结膀胱癌类器官的研究现状。方法:全面检索数据库,深入综述膀胱癌类器官模型的现状,重点介绍其在基础研究、临床转化和治疗发现方面的应用。结果:我们总结了目前膀胱癌类器官的研究,强调了它们的优势,如遗传保真度和高通量药物筛选能力。此外,我们还解决了挑战,包括它们对肿瘤微环境的有限代表和技术复杂性。最后,我们讨论了未来的发展方向,包括免疫治疗的整合,共培养系统的发展,以及非侵入性采样方法和类器官芯片系统的探索。结论:传统的临床前模型在模拟人类肿瘤的复杂性方面存在固有的局限性。类器官技术的出现为解决这一挑战提供了一种突破性的方法,为研究肿瘤生物学、基因改变、药物筛选和膀胱癌个性化治疗提供了一种创新工具。
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来源期刊
Bladder Cancer
Bladder Cancer Medicine-Urology
CiteScore
1.60
自引率
0.00%
发文量
35
期刊介绍: Bladder Cancer is an international multidisciplinary journal to facilitate progress in understanding the epidemiology/etiology, genetics, molecular correlates, pathogenesis, pharmacology, ethics, patient advocacy and survivorship, diagnosis and treatment of tumors of the bladder and upper urinary tract. The journal publishes research reports, reviews, short communications, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that expedites our fundamental understanding and improves treatment of tumors of the bladder and upper urinary tract.
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